The comprehensive hypothesis of coal and gas outburst (CAGO), which considers that the in situ stress, gas pressure and content, and physical-mechanical properties of coal are the key factors in determining the occurrence of CAGO, is accepted by international scholars. Tectonic stress is the horizontal in situ stress that plays a leading role in the control of CAGO. To study the control of tectonic stress field on CAGO, the Pingdingshan eastern mining area is taken as a research area, and the evolution law of the regional tectonic stress field and the distribution characteristics of the modern tectonic stress field are analyzed. Combined with the characteristics of CAGO in this area, the effects of the tectonic stress field on the geological structure distribution, gas occurrence and tectonic coal development are discussed, and the effects of the tectonic stress field on CAGO are further studied. The results show that the evolution of the tectonic stress field forms the geological structure pattern of the Pingdingshan eastern mining area, leading to the differences in the distribution of gas occurrence in different areas of the mine area and resulting in a large area of tectonic coal development. The modern tectonic stress field exacerbates the pulverization and mylonitization of tectonic coal and influences the gas pressure and content through the coal reservoir permeability. The modern tectonic stress is the direct cause of CAGO, increasing the possibility and risk of CAGO.
By observing a large number of conjugate shear joint data in the field and underground of the study area, the conjugate shear joint data is analyzed by the stereographic projection method, and the paleo-tectonic stress field experienced in the mining area since the Mesozoic is inferred. Based on the above research, the tectonic evolution process of the eastern mining area of Pingdingshan is discussed from the aspect of dynamic mechanism. The results show that: (1) The eastern mining area of Pingdingshan experienced the Indosinian, Yanshan early-middle, Yanshanian, and Xishanian tectonic stress fields, with the directions of NS, NW, NE, and NNE, respectively. (2) The tectonic evolution of the mining area can be divided into four stages: (a) The Indosinian tectonic stress field has the weakest effect on the study area, the coal-bearing strata are gradually uplifted by the stress field in this period, and some small structures are formed in the coal-bearing strata; (b) The early-middle Yanshanian tectonic stress field has a certain transformation effect on the coal-bearing strata in the eastern part of Pingdingshan. It mainly forms the secondary structure of the mining area such as Huoyan normal fault and small fault-fracture structure; (c) The late Yanshanian tectonic stress field has the strongest effect, and the control complex fold structure with the axis near NW direction is formed under the tectonic stress field of this period, such as Likou syncline, Baishishan anticline, Lingwushan syncline, Guozhuang anticline, Niuzhuang syncline, etc. The near-NW direction of the control fault structure is also formed under the action of the late Yanshanian tectonic stress field, such as the Niuzhuang reverse fault, the original No.11 mine reverse fault, etc.; (d) The Himalayan tectonic stress field mainly forms some secondary and small structures in the mining area and has a certain transformation effect on the structure formed by the early tectonic stress field. The tectonic pattern of the eastern mining area of Pingdingshan is the result of the above-mentioned tectonic stress field acting in sequence with the coal-bearing strata, causing structural deformation of the coal seam.
BackgroundLipid metabolism disorders can damage human health, and the changes in human intestinal flora are closely related to lipid metabolism disorders. Traditional Chinese medicine (TCM) can play a role in regulating intestinal flora and balancing intestinal microecology. In this meta-analysis, the role of oral preparations of TCM that regulate intestinal flora, in the prevention and treatment of lipid metabolism disorders, was systematically evaluated.MethodsThe databases CBM, Pubmed, Embase, CNKI, Wanfang, and Google Scholar were searched by rapid matching of keywords to obtain clinical controlled studies related to oral preparations of TCMs regulating intestinal flora. After screening and quality evaluation, meta-analysis was performed using Review Manager 5.3 software.ResultsTotal of 835 patients were enrolled in the 10 articles included in this study. Meta-analysis showed that TCM intervention could reduce the level of total cholesterol (TC) in patients with abnormal lipid metabolism [mean difference (MD) = −0.61, 95% confidence interval (95%CI) (−0.80, −0.42), p < 0.00001], reduce triacylglycerol (TG) level [MD = −0.46, 95%CI (−0.60, −0.33), p < 0.00001], increase high-density lipoprotein (HDL) level [MD = 0.25, 95%CI (0.17, 0.34), p < 0.00001], reduce the number of intestinal enterobacteria [MD = −0.64, 95%CI (−0.79, −0.49), p < 0.00001], reduce the number of enterococci [MD = −1.14, 95%CI (−1.66, −0.63), p < 0.00001], increase the number of intestinal lactobacillus [MD = 0.41, 95%CI (0.09, 0.74), p = 0.01], and increase the number of intestinal bifidobacteria [MD = 0.94, 95%CI (0.20, 1.68), p = 0.01].ConclusionThe application of oral preparations of TCMs that regulate intestinal flora, in the prevention and treatment of lipid metabolism disorders, can increase the colonization of beneficial bacteria in the intestine of patients, inhibit the growth of harmful bacteria, and restore the intestinal microecological balance, thus indirectly acting on the regulation of blood lipids in patients and contributing to the recovery of dyslipidemia.
Background: Chemotherapy has become the main means to prolong the life of patients with advanced digestive tract cancer; however, it is associated with serious toxicity and side effects. Compound Kushen Injection (CKI) is a pure Chinese herbal preparation, which can assist chemotherapy, inhibit tumor cell proliferation, and reduce adverse reactions of chemotherapy. In this study, we systematically evaluated reports of CKI as an adjuvant to chemotherapeutic treatment of digestive tract cancer in recent years and provided evidence for clinical diagnosis and treatment.Methods: The databases of PubMed, Chinese Biomedical Literature (CBM), China National Knowledge Infrastructure (CNKI) and Web Of Science were searched for clinical randomized controlled trials (RCTs) related to adjuvant chemotherapy with CKI in the treatment of advanced gastrointestinal tumors published from January 2000 to September 2021. After screening the qualified literatures, RevMan 5.4 software was used to evaluate the bias of the included literatures and perform meta-analysis.Results: A total of 12 articles were included in the selection, incorporating 1080 study participants in all; meta-analysis results showed that application of the CKI in the process of chemotherapy for digestive tract tumors could improve the efficacy [odds ratio (OR) =3.11; 95% confidence interval (CI): 2.26 to 4.47, Z=7.00, P<0.00001], increase the patients' median survival time (months) (OR =3.00; 95% CI: 1.47 to 4.52, Z=3.84, P=0.0001), increase the level of CD3 + [mean difference (MD) =4.11; 95% CI: 3.24 to 4.98], CD4 +
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.