Introduction One of the main problems of modern basketball physiology is maintaining high performance and improving its players’ physical condition. Changes in the athlete’s functional condition occur due to the transition of the physiological system from rest to stress, fatigue, and regeneration. Objective Clarify the effect of physical activity on homeostasis in athletes according to gender differences. Methods The methods of analysis and synthesis, comparative analysis, modeling, and logical analysis were applied. Results Positive and negative factors of the influence of physical activity on elementary homeostasis of professional basketball players depending on gender differences were assigned; also, the principles of selection of physical activity content and the methodological bases of application for use in training programs of professional basketball players were characterized. Conclusion The results of this study showed the need to control the elemental body homeostasis of basketball athletes and its changes in physical exertion conditions, considering personal characteristics and gender differences. Evidence level II; Therapeutic studies - outcomes research.
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