H]arginine binding to BA 9 did not differ between groups, and there was no specific binding of [ 3 H]raclopride or 7-hydroxy-2-(di-n-[ 3 H]propylamino)tetralin to BA 9 from either cohort of subjects. This suggests the density of dopamine D 1 -like and NMDA receptors, the dopamine transporter, and nitric oxide synthase activity are not altered in BA 9 from schizophrenic subjects. The selective nature of the changes in serotonin 2A and GABA A receptors in DLPFC could indicate that these changes are involved in the pathology of schizophrenia.
The A(–1438)G promoter polymorphism of the 5-hydroxytryptamine 2a receptor (5-HT2AR) gene and its influence on the cortical density of 5-HT2AR was studied using brain tissue donated at autopsy from 58 schizophrenic and 64 non-schizophrenic subjects. A linkage between genotypes for the A(–1438)G and a T102C polymorphic site identified in a previous study was observed. Our data suggest no association of the A(–1438)G polymorphism with schizophrenia and no effect of the promoter genotype upon 5-HT2AR densities in either the schizophrenic or non-schizophrenic groups.
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