In recent years,
antibacterial surface
modification of titanium (Ti) implants has been widely studied in
preventing implant-associated infection for dental and orthopedic
applications. The purpose of this study was to prepare a composite
coating on a porous titanium surface for infection prevention and
inducing mineralization, which was initialized by deposition of a
poly-
l
-lysine (PLL)/sodium alginate(SA)/PLL
self-assembled coating, followed by dopamine deposition, and finally
in situ reduction of silver nanoparticles (AgNPs) by dopamine. The
surface zeta potential, SEM, XPS, UV–vis, and water contact
angle analyses demonstrate that each coating was successfully prepared
after the respective steps and that the average sizes of AgNPs were
20–30 nm. The composite coating maintained Ag+ release
for more than 27 days in PBS and induced mineralization when incubated
in SBF. The antibacterial results showed that the composite coating
inhibited/killed bacteria on the material surface and killed bacteria
around them. In addition, although this coating inhibited the initial
adhesion of osteoblasts, the mineralized surface greatly enhanced
the cytocompatibility. Thus, we concluded that the composite coating
could prevent bacterial infections and facilitate mineralization in vivo in the early postoperative period, and then, the
mineralized surface could enhance the cytocompatibility.
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