We describe artificial DNA molecules exclusively consisting of four types of alkynyl C-nucleotides with nonnatural bases. The artificial DNA exhibited almost the same characteristics as natural DNA, such as in regard to the stepwise duplex and triplex formation and the right-handed higher-order structure with an antiparallel alignment fashion.

No abstract

No abstract

Sonogashira reaction of ethynyldeoxyribofuranoside (I) with halogenated pyridine or pyrimidine derivatives is improved by using hexamethyldisilazane/DMF mixed solvent. -(INOUYE*, M.; DOI, Y.; AZUCHI, J.; SHIRATO, W.; CHIBA, J.; ABE, H.; Heterocycles 82 (2011) 2, 1137-1141, http://dx.doi.org/10.3987/com-10-s(e)89 ; Grad. Sch. Pharm. Sci., Univ. Toyama, Toyama 930, Japan; Eng.) -R. Langenstrassen 31-191