The application potential of wearable electronics in the healthcare field has been of great interest over the past several decades. Flexible and wearable devices based on skin-friendly soft elastic materials can be snugly attached to the surface of human skin, so that a series of vital health information such as wrist pulse, body temperature, and blood glucose can be extracted and analyzed to help the patient maintain physical fitness. Here, we outlined the most common types of wearable electronics for monitoring human health information, including force sensors, temperature sensors, physiological biochemical sensors, and multifunctional sensors. Their general working principles and structural innovations are reviewed. Then, we discussed two functional modules that make the wearable sensors more applicable in real life—self-powered module and signal processing module. The challenges and future research directions are also proposed to develop wearable electronics for monitoring human health information.

Purpose: Capecitabine plus oxaliplatin (CAPOX) is one of the standard first-line treatments for unresectable, advanced, or metastatic gastric or gastroesophageal junction (G/GEJ) adenocarcinoma. Camrelizumab shows promising antitumor activity in advanced or metastatic G/GEJ adenocarcinoma in a phase I study. We reported the outcomes of cohort 1 in a multicenter, open-label, phase II trial, which assessed camrelizumab in combination with CAPOX followed by camrelizumab plus apatinib as a first-line combination regimen for advanced or metastatic G/GEJ adenocarcinoma. Patients and Methods: Systemic treatment-naïve patients with EGFR2-negative advanced or metastatic G/GEJ adenocarcinoma received initial camrelizumab plus CAPOX for 4–6 cycles, and patients without progressive disease were administrated subsequent camrelizumab plus apatinib. Primary endpoint was objective response rate (ORR). Results: All 48 enrolled patients comprised the efficacy and safety analysis population. The ORR was 58.3% [95% confidence interval (CI), 43.2–72.4] with this combination regimen. Median duration of response was 5.7 months (95% CI, 4.4–8.3). Median overall survival was 14.9 months (95% CI, 13.0–18.6), and median progression-free survival was 6.8 months (95% CI, 5.6–9.5), respectively. The most common grade ≥3 treatment-related adverse events (>10%) were decreased platelet count (20.8%), decreased neutrophil count (18.8%), and hypertension (14.6%). Treatment-related death occurred in 1 patient (2.1%) due to abnormal hepatic function and interstitial lung disease. Conclusions: Camrelizumab combined with CAPOX followed by camrelizumab plus apatinib demonstrated encouraging antitumor activity and manageable toxicity as first-line therapy for patients with advanced or metastatic G/GEJ adenocarcinoma.

Unsupervised neural machine translation (NMT) is a recently proposed approach for machine translation which aims to train the model without using any labeled data. The models proposed for unsupervised NMT often use only one shared encoder to map the pairs of sentences from different languages to a shared-latent space, which is weak in keeping the unique and internal characteristics of each language, such as the style, terminology, and sentence structure. To address this issue, we introduce an extension by utilizing two independent encoders but sharing some partial weights which are responsible for extracting high-level representations of the input sentences. Besides, two different generative adversarial networks (GANs), namely the local GAN and global GAN, are proposed to enhance the cross-language translation. With this new approach, we achieve significant improvements on English-German, English-French and Chinese-to-English translation tasks.

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Education programmes appear to have beneficial effects on improving patients' knowledge of diabetes and some self-management behavioural changes for patients with diabetes on dialysis or with microalbuminuria. Educational programmes appear to have beneficial effects on improving patients' self-efficacy and result in some beliefs changes for patients with diabetes and microalbuminuria. However, only two studies with small sample sizes and inadequate quality were included in this review. There is, therefore, inadequate evidence to support the beneficial effects of education programmes for people with DKD.