AbstrakJumlah penderita kanker kolon yang tinggi mendorong penelitian akan pengobatan yang lebih efektif dan mengurangi efek samping dari pengobatan masa kini, salah satunya adalah dengan pengobatan secara herbal. Kulit buah kakao (Theobroma cacao) memiliki kandungan pektin yang diketahui dapat menekan pertumbuhan sel kanker. Penelitian ini bertujuan untuk mengetahui potensi aktivitas antikanker kolon dari pektin kulit buah kakao (Theobroma cacao) pada tikus yang diinduksi dengan 7,12-dimethylbenzen(α)anthrasena (DMBA) dengan dosis 20 mg/kgBB. Tikus dikelompokkan menjadi empat kelompok yaitu kelompok I kontrol negatif, kelompok II pektin dosis 8 mg/kgBB, kelompok III pektin dosis12 mg/kgBB, dan kelompok IV pektin dosis 16 mg/kgBB. Hasil penelitian menunjukkan dosis uji tertinggi, yaitu 16 mg/kgBB memberikan aktivitas terbaik dalam memulihkan kembali sel goblet yang rusak akibat induksi dari senyawa karsinogen. Dengan demikian dapat disimpulkan bahwa pektin kulit buah kakao (Theobroma cacao) memiliki potensi aktivitas antikanker kolon pada dosis uji.Kata kunci: DMBA, kulit buah kakao, pektin, sel goblet AbstractThe high incident of patient with colon cancer, promotes the research for more effective treatments and reduce side effects of treatment today, one of them is with herbal treatment. Cacao pod husk (Theobroma cacao) has a pectin which is known to suppress the growth of cancer cells. This study aims to determine the potential anticancer activity of the extract cocoa pod husk (Theobroma cacao) in the colon of rat induced by 7,12-dimethylbenzen (α) anthrasena (DMBA) at a dose of 20 mg/kg. The rat were grouped into four groups: group I as control negative, group II given diet pectin dose of 8 mg/kgBW, group III given diet pectin dose 12 mg/kgBW, and group IV given diet pectin dose 16 mg/kgBW. The results showed the pectin dose 16 mg/kgBW, the highest dose gives the best activity to recovering goblet cell that damaged by induction of compound carcinogens. Thus it can be concluded that cacao pod husk (Theobroma cacao) has potential anticancer activity of the colon at that dose.
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