We investigated induction of chromosome aberrations (CA) in human lymphocytes when exposed to 150 MeV and spread out Bragg peak (SOBP) proton beams, and 199 MeV/u carbon beam which are currently widely used for cancer treatment and simultaneously are important components of cosmic radiation. For a comparison, the boron ions of much lower energy 22 MeV/u and a
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Co γ rays were used. Dose–effect curves as well as the distributions of CA were studied using Poisson and Neyman type A statistics. Systematics of experimentally determined parameters, their dependence on applied doses and irradiation quality are presented.
A new statistical method to study repair mechanism of individual cells exposed to ionizing radiation is presented. The method is based on deviations from the Poisson distribution of observed chromosome aberrations and allows to determine the efficiency of repair mechanisms of individual cells. On basis of the dose-effect curves and the chi-square analysis, the ratio between the variance and the mean value of the observed aberration distribution could be calculated and related to the efficiency of the cellular repair mechanisms. The method has been tested on human lymphocytes and CHO-K1 cells exposed to different radiation species. In the case of high-linear energy transfer ion irradiation a correction due to Neyman A statistics has been introduced.
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