The infectious process caused by parvovirus B19 should be considered as a stressor effect on the body, which can significantly modulate its reactivity. In 129 infected pregnant women and 16 women with physiological pregnancy in I, II and III trimesters, the parameters characterizing the functional state of neutrophils (Nph) and monocytes (Mc) of peripheral blood were investigated. In infected pregnant women was observed an increase of the number of phagocytic cells and an increase of the intra cellular oxygen-dependent metabolism of Nph and Mc. In this case, through out the course of pregnancy, a decrease in the absorption capacity of phagocytes was noted in infected patients. In the I–III trimesters of pregnancy in women with B19 infection, the spontaneous and induced NBT-tests of Nph and Mc peripheral blood were increased in comparison with the control, but a significant difference was established only for blood Nph in women of group I. The greatest deviations from the control indicators were recorded in the first trimester of pregnancy. More pronounced above changes of the functional state of Nph and Mc were determined in infected patients with clinical complications of pregnancy.
Clinical and diagnostic data of 129 cases of parvovirus B19 infection during pregnancy are presented. Serological and virological results ofparvovirus infection examination of pregnant women and fetuses were evaluated. In 50.4% of cases, the main factor ofdiseasetransmissionis physical contact of pregnant woman with children who had infectious erythema. Parvovirus infection is diagnosed in 27% of casespregnant women at a risk of intrauterine infection during pregnancy. In 38% of pregnant women, the infection is asymptomatic and can be accidentally detected by the method of determining antibodies to parvovirus B19. In 62%cases maternal and fetal symptoms manifest in parvovirus infection during pregnancy. In 70% of maternal symptoms correlates with fetus symptoms. Diagnosis of transplacental transmission of parvovirus B19 with symptomatic manifestations of infection occurs in 36.4%. The main clinical symptom of fetal parvovirus infection is the development of non-immune hydrop. In the structure of echographic diagnosis of intrauterine anomalies of fetal development, parvovirus infection occurs in 4.7%. Key words: parvovirus infection, pregnancy, symptomatology, diagnostics.
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