In two papers (Finn et al., 1961 ;Clarke et al., 1963) we described experiments which were successful in preventing Rh immunization in Rh-negative male volunteers. The basis of the procedure was to remove rapidly from the circulation previously injected chromium-tagged Rh-positive red cells by giving hightitre incomplete anti-D either as an infusion of plasma or as gamma2-globulin. The remaining five females acted as controls and received no antibody. The procedure was repeated three and six months later. Serum was obtained from the subjects at these times and again at least six months after the last stimulus, and was tested for the presence of complete and incomplete immune antibodies.
ResultsThe results are shown in Table I, from which it will be seen that in each of the treated volunteers the foetal cells were rapidly cleared from the circulation by the anti-D gamma2-globulin. In the controls, on the other hand, the foetal scores generally remained much higher, though there are some results
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