Polyheterocyclic pyrimidinyltheophyllines have been synthesized from pyrimidine and theophylline precursors. Attempts to cyclize these reactive bis‐heterocyclic systems resulted in the formation of the corresponding diazepine moieties. In addition, modification of the reaction conditions led to the formation of imidazo[2,1‐f]purines.
At the process of ethyl 6‐methyl‐4‐aryl‐2‐thioxo‐1,2,3,4‐tetrahydropyrimidine‐5‐carboxylates condensation with aryl aldehydes and chloroacetic acid the unexpected formation of 5‐arylidenethiazolidine‐2,4‐diones was determined in high yields as the reaction time was increased to 20 h. The latter represent the products of destructive hydrolyzes of ethyl 2‐benzylidene‐7‐methyl‐3‐oxo‐5‐aryl‐2,3‐dihydro‐5H‐[1,3]thiazolo[3,2‐a]pyrimidine‐6‐carboxylates which have been proved by independent synthesis. J. Heterocyclic Chem., (2010).
Theophyllinylpyrimidine Scaffolds Undergo Intramolecular Cyclization Reactions to Form 1,3-Diazepines and Imidazopurines. -(LEBEDYEVA*, I. O.; POVSTYANOY, V. M.; RYABITSKII, A. B.; PANASYUK, O.; IVAHNENKO, E.; LOZOVA, V. P.; MARKEVICH, I.; ALLAKHVERDOVA, S.; POVSTYANOY, V.; Eur. J. Org. Chem. 2013, 21, 4594-4606, http://dx.
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