Modern industrial poultry farming occupies a leading position in the production of dietary foods, for which it is appropriate to use biologically active substances and probiotics. The study compared the effectiveness of compound feed with the addition of sodium selenite, bio-nano-selenium and L. plantarum in terms of body weight, weight gain, feed consumption and safety of experimental quail. The quails of the Pharaoh meat breed were kept in the vivarium of Bila Tserkva National Agrarian University and by the method of analogues were divided into 4 groups - control and three experimental ones. The duration of the study was 35 days. The results of the study indicate that the use in the quail’s diet of probiotics (L. plantarum) and selenium preparations (sodium selenite and bio-nano-selenium) leads to a predominance of poultry experimental groups in live weight over control analogs. It was found that the growth of bird’s live weight during the experiment differed depending on the use of the Selenium medication or probiotic, and the most intense effect on live weight of quails was the use of bio-nanоselenium in the diet of poultry (11.8% at the end of the experiment). Changes in absolute and average daily body weight gains of experimental birds have been clarified. The use of sodium selenite in the diet of quail caused a tendency for an increase in gains compared with control analogs at the beginning of the study and a downward trend during the fifth week of the study. It was found that the use of probiotics and bio-nano-selenium caused an increase in quail growth, which was more pronounced and reliable when feeding bio-nano-selenium. The obtained results show that probiotic and selenium preparations reduce feed consumption by 1 kg of weight gain, body weight increase by 3.05–11.8% and by 3.3–6.6% increase the safety of the experimental livestock with the best indicators in the group, receiving bio-nano-selenium.

The presented analytical review summarizes the data of the world and national literature on the features of the accumulation of microelement nanoparticles in the body, their effects on metabolism, redox processes and productivity of poultry. The attention is paid to the toxicity of various forms and sources of the considered elements, their mutual influence on bioavailability, antagonism and the rate of excretion. The need to study the peculiarities of the use of nanoparticles and their efficiency in the production of livestock products is constantly increasing. Evidence of the positive application of nanoforms of elements (zinc, silver, selenium, cerium, iron) in the diets of different species of farm poultry is considered due to their metabolic, antimicrobial action, influence on digestion and regulation of bowel function. Analyzed data indicate that nanoparticles of metals and non-metals in animal husbandry are an alternative to feed antibiotics for antibacterial action, increase the productivity of animals and poultry, can activate metabolism by stimulating the activity of hormones, optimize the immune response of the organism, induce syntheses and metabolism. Nanoparticles of metals and non-metals have been found to reduce the mineral antagonism in case of contact with the intestine, which contributes to the efficiency of digestion. Changes in the prooxidant-oxidant status of the blood of animals by the use of test nanoparticles and changes in homeostasis indices that are positive for poultry due to increased productivity, intensification of egg production, their weight and fertilization rate of hatching eggs have been established. Influence of nanoparticles on redox homeostasis and processes of lipid and protein peroxidation are established. The use of nanoscale drugs for use in biology, medicine, veterinary medicine, agriculture, and the need for further research to study all possible mechanisms of biological action of nanostructures are argued. Key words: trace elements, nanoparticles, poultry, feeding, silver, zinc, selenium, cerium dioxide.

chain of agricultural production, as well as in the food industry, which will promote the creation of new nanomaterials, is shown. Nanotechnologies are successfully used to ensure the quality of food, enrichment of food products with minerals, vitamins, antioxidants, improvement of organoleptic properties, prolongation of life and antimicrobial packaging of food products. The focus is on the biosafety of nanomaterials whose properties are multifaceted, ambiguous and require a comprehensive, safe, responsible and scientifically sound approach. ARTICLE INFO

At present, nanotechnology is taking the leading role in various industries, medicine, and agriculture all over the world. Fundamentally different properties are inherent in nanoparticles, in particular, a high capacity for accumulation in living organisms by overcoming biobarriers, increasing bioavailability and binding with the main components of cells. The article studies the peculiarities of the influence of cerium dioxide nanoparticles on metabolic pathways in the body of broiler chickens. The data on the use of metal nanoparticles, in particular, a material based on cerium, as an alternative to feed antibiotics for increasing the productivity of livestock and poultry farming has been analyzed. The aim of this work was to investigate the effect of cerium dioxide nanoparticles on the biochemical blood profile of chickens with meat production. For the studies carried out at the Research Institute of Ecology and Biotechnology of the Bila Tserkva NAU, a new multifunctional antioxidant was used - nanodispersed cerium dioxide, developed by the D. K. Zabolotny Institute of Microbiology and Virology of the NASU, Ukraine. For the scientific and economic experience there were formed 3 groups of broilers of the ROSS 308 cross according to the principle of analogous groups (control and 2 experimental groups, 100 heads each). For 58 days, the experimental groups of birds with drinking water were added nanodispersed cerium dioxide at a dose of 8.6 mg/l during the first 14 days. Course was repeated after 7 (group 1) and 14 days (group 2) breaks. As a result of the studies, it was found that the blood parameters of broilers, characterizing the main types of metabolism were within the physiological norm. There was a tendency to activation of lipid and protein metabolism, which contributed to the intensification of the growth of young animals. The use of nanodispersed cerium dioxide as a promising material for increasing the productivity of poultry farming and as an alternative to feed antibiotics is argued. In further studies, it is advisable to study the action of cerium dioxide nanoparticles to study all possible mechanisms of its biological activity.