Dietary iron loading resulted in a substantially increased DOX cardiotoxicity in rats. Body iron stores as well as its bioavailability in tissue may be important independent predictors of susceptibility to DOX cardiotoxicity in man. Further clinical studies are warranted.

No abstract

Inflammatory bowel disease (IBD) is a chronic relapsing gastrointestinal tract disease. There is an upsurge of IBD cases worldwide and there is no gold standard therapy and the drugs used to treat IBD are having many major side effects. Thus, there is a need for a better treatment option. This study aimed to evaluate the prophylactic role of Avena sativa (oat) in 2, 4-dinitro benzene sulphonic acid (DNBS) (120 mg kg-1) induced IBD in rats. Animals were randomly allocated to five groups- negative control, model control receiving only DNBS, group receiving A. sativa extract (500 mg kg-1 and 1 g kg-1 p.o.) and the last group receiving sulphasalazine (100 mg kg-1, p.o.). Colitis-induced rats treated with A. sativa and sulphasalazine restored their body weight, stool consistency, and bleeding in stool and significantly improved several biochemical parameters such as colonic glutathione content, lactate dehydrogenase, myeloperoxidase and lipid peroxides levels as compared to the model control group. Findings suggest that A. sativa possesses antioxidant and anti-inflammatory activity and can be useful in treating IBD.