The first isolation of the rabies virus in frugivorous bats of the species Artibeus lituratus in Montes Claros, State of Minas Gerais, is presented. The diagnosis was obtained through the direct immunofluorescence reaction, biological tests and viral profiling. Although canine rabies is under control in this city, the rabies virus continues to circulate in bats in the urban area.
Hypertrichosis and dental anomalies may occur alone or in combination in the spectrum of many syndromes. To identify genetic entities characterized by hypertrichosis and dental anomalies, a search was performed in the Mendelian Inheritance in Man database with the terms "hypertrichosis" or "hirsutism" and "tooth" or "dental abnormalities." Nondependent androgen metabolism disturbances were classified as hypertrichosis. Genetic entities with hypertrichosis and dental anomalies were included in the study. Additional searches were performed in the PubMed and Orphanet databases, when necessary, in order to include data from scientific articles. An integrative analysis of the genes associated with the identified syndromes was conducted using STRING to characterize biological processes, pathways, and interactive networks. The p-values were subjected to the false discovery rate for the correction of multiple tests. Thirty-nine syndromes were identified, and dental agenesis was the most frequent dental anomaly present in 41.02% (n = 16) of the syndromes. Causative genes were identified in 33 out of 39 genetic syndromes. Among them, 39 genes were identified, and 38 were analyzed by STRING, which showed 148 biological processes and three pathways that were statistically significant. The most significant biological processes were the disassembly of the nucleosome (GO:0006337, p = 1.09e-06), chromosomal organization (GO:0051276, p = 1.09e-06) and remodeling of the chromatin (GO: 0006338, p = 7.86e-06), and the pathways were hepatocellular carcinoma (hsa05225, p = 5.77e-05), thermogenesis (hsa04714, p = 0.00019), and cell cycle (hsa04110, p = 0.0433). Our results showed that the identification of hypertrichosis and dental anomalies may raise the suspicion of one of the thirty-nine syndromes with both phenotypes.
O câncer de pele não-melanoma é a neoplasia maligna mais comum no Brasil. Seu subtipo menos frequente, o carcinoma espinocelular (CEC), pode ser agressivo, mas, na maioria das vezes, é completamente curado por medidas terapêuticas locais. Relatamos o caso de uma mulher de 75 anos que apresentava lesão de 2,5 cm em dorso da mão esquerda diagnosticada como CEC bem diferenciado. Foi submetida à ressecção da lesão com margem cirúrgica de 1,5 cm. Após 75 dias da cirurgia, paciente retornou com linfadenomegalia axilar esquerda. Foi realizada biópsia, que conclui tratar-se de CEC bem diferenciado metastático. O tratamento proposto foi linfadenectomia axilar com radioterapia adjuvante. Paciente evoluiu com recidiva axilar ulcerada e dor intensa, sendo realizada ressecção ampliada da lesão. Foi proposto à paciente desarticulação interescapulotorácica e a paciente concordou com a realização do procedimento. Atualmente, encontra-se em controle ambulatorial, sem sinais de recidiva ou metástases à distância. O caso clínico mostra uma evolução atípica de um CEC bem diferenciado, com lesão primária em dorso da mão esquerda e metástase linfonodal axilar precoce, com comprometimento da qualidade de vida. Optamos pela desarticulação interescapulotorácica devido à presença de um tumor localmente avançado, a não funcionalidade do membro, a possibilidade de melhor higienização local e a ausência de metástases em outros sítios. Palavras-chave: Câncer de pele. Carcinoma Espinocelular. Metástase. Recidiva. Desarticulação interescapulotorácica.
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