Vigabatrin (VGB) is a drug of Anticonvulsant class. It works by decreasing abnormal electrical activity in the brain. It inhibits the GABA-degrading enzyme i.e. GABA transaminase, it increases the GABA concentrations in the brain. Vigabatrin is used for the treatment of refractory complex partial seizures in adults and also used for children 2 years of age and older and infantile spasms in children. Vigabatrin was approved for anticonvulsant medication by USFDA on August 21, 2009. Therefore, in the present review article, we have enlisted different analytical method such as Ultraviolet (UV) visible spectroscopy, High-performance liquid chromatography (HPLC), Ultra-performance liquid chromatography (UPLC) and Gas Chromatography for both qualitative and quantitative analysis of VGB in pharmaceutical and biological. In the future, this review article will assist researchers regarding the development of a new analytical method for VGB.
Risperidone (RIS) is an atypical antipsychotic medication. This works by selectively antagonising serotonin 5HT2 and dopamine D2 receptors. It's used to treat schizophrenia and other mental illnesses. As per literature, RIS was first approved USA by Food and drug administration (FDA) in 1993. Therefore, the main objective of this analysis of RIS in pharmaceutical and biological formulation is in both qualitative and quantitative terms. In this review article, we have summarized UV/Vis spectroscopy, high-performance liquid chromatography (HPLC), High-performance thin-layer chromatography (HPTLC), Liquid chromatography-mass spectroscopy-mass spectroscopy (LC-MS/MS) etc. based methods for estimation of risperidone. In addition to that, we have discussed the bioanalytical methods for RIS analysis. In conclusion, this review article will help to research scholars for further method development for drug estimation in pharmaceutical dosage forms and biological fluids.
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