We report the case of a 47-year-old male patient with S100 negative granular cell
tumor of the oral cavity, focusing on dermoscopic features as well as surgical
approach, not previously reported in the literature. The study contributes to
the literature on dermoscopy and surgical treatment for this tumor and provides
a practical approach to differentiating non-neural granular cell tumors and
granular cell tumors.
Morbidity and mortality caused by tuberculosis are increased in most of the Latin-American indigenous communities. Factors that could explain this situation are poverty and limited health services access due to social conflicts and geographical isolation. We determined the frequency of tuberculosis in Colombian indigenous communities and described their knowledge related to transmission and control. We developed a descriptive study and health survey. Interviews were performed to find ancestral knowledge about tuberculosis. Sputum samples from patients with respiratory symptoms were analyzed. 10 indigenous communities were studied, which tuberculosis incidence was 291/100,000. Communities believe that tuberculosis is a body and spirit disease, which transmission is by direct contact or by witchcraft. Tuberculosis incidence in the studied communities was ninefold higher than that of the general population from Antioquia Department. Knowledge exchange could facilitate the community empowerment and implementation of educational activities which might improve the control of the disease.
In recent years, there have been great advances in the development and approval of new targeted therapies for the treatment of neoplasms both in children and in adults. Mitogen-activated protein kinase inhibitors (MEKi) have been used for the treatment of central nervous system tumors in children such as neurofibromas and gliomas, with promising results. 1 Adverse effects (AEs) are well known in adult patients; however, few studies exist in the pediatric population. [1][2][3] Cutaneous AEs are among the most common toxicities described. We aimed to describe the cutaneous AEs associated with MEKi in pediatric patients.
| MATERIAL S AND ME THODSA retrospective study was carried out at our pediatric hospital in Barcelona, Spain. Clinical records of all patients under 18 years of age undergoing therapy with MEKi between January 2015 and June 2019 were reviewed. Children with less than 3 months follow-up after starting therapy were excluded. Before starting therapy, children were seen by a pediatric dermatologist who provided education regarding possible cutaneous AEs, with recommendations regarding sunscreen use, daily bathing and emollient use, the wearing of comfortable shoes, and nail care. The frequency and onset of cutaneous AEs were recorded. Data were
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.