The bioactivity of the PLA/d-HAp nanocomposite with 30 wt.% d-HAp was evaluated by in vitro tests and indicated that after 7 immersion days in SBF solution, PLA amorphous part was hydrolyzed and PLA crystal part was remained. The formation of apatite on the surface of the material was observed. The in vivo test results of PLA/d-HAp nanocomposite (70/30 wt/wt) on femur of dogs displayed that 3 months after grafting, the materials did not induce any osteitis, osteomyelitis or structural abnormalities. The histological and x-ray image demonstrated a growth of the bone into the material area, while osteitis and osteomyelitis were not observed.
Gastric cancer (GC) is the remaining concern of cancer-associated health burden. Valuable predictive and prognostic indicators support the early diagnosis and improve outcome. Immune escape and inflammation are important cancer hallmarks. The prognostic and diagnostic value of platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) was reported in some cancers. But these cheap and convenient indexes are far from clinical use. Thus, investigation the alteration of those index on GC is needed to impose the use of those indexes in clinic. The study recruited seventy-seven hospitalized patients newly diagnosed with GC and 90 healthy individuals. The clinical and preclinical data of participants were collected from Hospital Information Management system. This study were approved by the Ethical Committee, Vietnam Military Medical University. The data were analyzed on STATA version 14.0 and GraphPad Prism 8.0. The alteration of immunological system was reported by significantly higher white blood cell count, neutrophils, platelets, PLR, and NLR as well as decreased lymphocytes on GC, compared to healthy individuals. Those indexes were elevated on advanced stage GC, compared to early stage GC. Our receiver operating characteristic curve analysis showed the significant specificity and sensitivity of PLR (cutoff 135.0) and NLR (cutoff 2.0) on GC diagnosis with respective area under receiver operating characteristic curve of 84.74% and 85.17%, P < .0001. Besides, our results reported the tendency of increased PLR and NLR and short time from clinical signs to being diagnosed. PLR and NLR have significant specificity and sensitivity in diagnosis and prognosis of GC.
Objectives: To investigate plasma erythropoietin (EPO) concentration and its relationship with some characteristics in type 2 diabetic patients (T2DM) with chronic kidney injury (CKI). Subjects and methods: A cross-sectional descriptive study on 219 subjects, including 129 patients with type 2 diabetes with chronic kidney injury, 51 patients with diabetes without CKI as a disease control group, and 39 healthy people as a normal control group. All subjects had their plasma EPO levels quantified by ELISA. Results: The median EPO concentration of the research group was 35.83 (21.55 - 56.34) UI/L, lower than the disease control group, which was 44.72 (37.25 - 63.90) UI/L, and lower than the normal control group, which was 113.31 (30.55 - 378.42) UI/L, p < 0.001. The rate of EPO reduction in the study group was 41.9%. EPO concentration was positively correlated with GFR, r = 0.242, p < 0.01. Creatinine is an independent factor associated with reduced EPO, p < 0.05. Conclusion: The rate of EPO reduction in the type 2 DM group with CKI was 41.9%. Decreases in EPO levels are common in KI patients with type 2 diabetes and are associated with decreased GFR.
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