Complex analysis of development of cells of liver -hepatocytes in the biocompatible scaffold, fabricated of porous-permeable TiNi-based alloy has been performed. Specific stages of development of cellular population in pores of scaffold are displayed in the present investigation. The stepwise characteristic of developing of hepatocytes in porous-permeable structure from TiNi-based alloy is demonstrated. Nanoporous surface of pores in incubator permit cells to be reliably fixed and produce growth to cellular colonies, and porous-permeable structure of scaffold allows penetrating to nutrients from environment during all time of investigation in vivo. Examination on CCl4-induced hepatitis has displayed effective antitoxic activity of population of hepatocytes in scaffold from TiNi-based alloy and their prolonged effect.
We studied morphological features of the regenerate formed after postresection defect plasty of the pericardium, diaphragm, and thorax with a mesh implant made of nanostructural titanium-nickelide threads. The newly formed tissue grew through the implant with the formation of an integrated tissue regenerate ensuring anatomic and physiological restoration of this area.
This article describes original surgical methods and the results of reconstruction of postresectional pericardium defects, diaphragm defects and chest wall defects with the use of nickel-titanium implants. The aspects of integration of developed surgical methods and methodology in the creation of implants by means of modern computer technologies during surgical planning in thoracic oncology are presented.The aspects of integration were first studied during surgical experiments on animals and then the following application in clinics. The reconstruction of pericardium defects in 17 cases, the diaphragm defects reconstruction in six cases and chest wall defects reconstruction in six cases will be presented. Satisfactory and excellent functional results were achieved following the surgeries. Respiratory function disorders and instability of the rib cage were not revealed in the late postoperative period under the dynamic control.
Аннотация. Проведено исследование развития β-клеток поджелудочной железы в инкубаторе-носителе клеточных культур, изготовленном из пористо-проницаемого никелида титана. Установлены особенности развития клеточного материала внутри пор и поэтапный рост β-клеток в пористо-проницаемой структуре инкубатора из никелида титана. Развитая микропористая поверхность стенок пор инкубатора создает условия для закрепления и роста колоний β-клеток поджелудочной железы, а взаимосвязанная пористопроницаемая структура инкубатора обеспечивает проникновение и обмен питательных веществ с внешней средой. Исследование на патофизиологической модели аллоксанового диабета показало эффективное антидиабетическое действие популяции β-клеток поджелудочной железы в инкубаторах из пористого никелида титана и их пролонгированный эффект. Предварительные результаты клинического изучения показывают эффективность использования гибридного искусственного органа на пористо-проницаемой матрице из никелида титана для комплексного лечения метаболических заболеваний и их коррекции. Ключевые слова: пористо-проницаемый инкубатор, β-клетки поджелудочной железы, никелид титана.
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