No abstract

Human herpes virus-6 (HHV-6) is a DNA virus with two known subtypes A and B. It is unique as its genome integrates into that of humans and is transmitted through the germ cells to the progeny, which is the major mode of vertical transmission (86%) compared to transplacental transmission (14%). 1 Chromosomally integrated HHV-6 (ciHHV-6) is diagnosed by the detection of HHV-6 DNA in hair follicles and/or nail clippings while it will be absent in transplacental infection. 2 We present a neonate who presented in shock after birth, was diagnosed with ciHHV-6Aassociated myocarditis and was successfully treated with artesunate, an antimalarial drug with antiviral properties.

Pulmonary hypertension (PH) in the term newborn is associated with roughly one-fifth higher mortality and morbidity. The diagnosis of PH is confirmed by echocardiogram based on established criteria, including assessment of cardiac function, size of the shunts, and presence of hypovolemia. The elementary steps in the management of PH are supportive measures followed by oxygenation, ventilation including possibly high frequency ventilation; lung recruitment and surfactant therapy. Ventilation strategies are based on the etiology of persistent pulmonary hypertension of the newborn (PPHN)-like lung parenchymal disease, or hypoplasia. Oxygenation index (OI) or oxygen saturation index (OSI) are the parameters used for monitoring the disease progression and treatment. Surfactant is given if OI >5 in PPHN due to underlying lung disease, and pulmonary vasodilators such as sildenafil are contemplated if OI <15 and inhaled nitric oxide (iNO) if OI >15. If iNO and sildenafil fail, the options available are milrinone, bosentan, adenosine, and prostaglandins. Extra corporeal membrane oxygenation is the final option available with OI >40. A structured algorithmic approach for the management of PH in term infants is discussed in this review. Novel therapies targeting specific pathways in the pulmonary vasculature are under investigation.

BACKGROUNDNNH is a common problem in neonates during 1 st week of life. Early discharge of healthy-term newborn is a common practice and NNH is a cause for readmission in most babies. Our aim was to predict the risk of NNH using cord bilirubin values.

We all stand at the threshold of the digital era where mobile and digital health is going to be the norm. A number of apps are available on the iOS and android platforms for health workers in neonatology. In this article, we have compiled the information regarding various apps related to neonatology available for android and iOS mobile devices.