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Ongoing work shows that misplaced epithelial cells have the capacity to reintegrate back into tissue layers. This movement appears to underlie tissue stability and may also control aspects of tissue structure. A recent study reveals that cell reintegration in at least one tissue, the Drosophila follicular epithelium, is based on adhesion molecules that line lateral cell surfaces. In this article we will review these observations, discuss their implications for epithelial tissue development and maintenance, and identify future directions for study.

The rapid increase in bacterial resistance to antibiotics is a global healthcare crisis. Non-antibiotic pharmaceuticals that have attained approval by the United States Food and Drug Administration have the potential to be repurposed as bacterial resistance-modifying agents and therefore could become valuable resources in our battle against antibiotic-resistant microbes. Amoxapine is a tetracyclic antidepressant used in the treatment of major depressive disorder. Here we demonstrate the ability of amoxapine to resensitize methicillin-resistant Staphylococcus aureus strain ATCC 43300 to oxacillin in both agar diffusion and broth microdilution assays. Amoxapine also reduced the bacterial cleavage of nitrocefin in a dose-dependent manner, suggesting that it may exert its adjuvant effects through reduction of beta-lactamase activity.

Generic Framing Procedure (GFP) is a new standard that has been developed to overcome data transport inefficiencies or deficiencies with the existing ATM and Packet over SONET/SDH protocols. Transparent GFP (GFP-T) is an extension to GFP developed to provide efficient lowlatency support for high-speed WAN applications including storage area networks. Rather than handling data on a frame-by-frame (packet-by-packet) basis, GFP-T handles block-coded (e.g., 8B/10B) character streams. This article describes the GFP protocol along with technical considerations and applications for transparent GFP.

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