Latar Belakang: Peningkatan angka penderita sindrom metabolik secara global dianggap mengkhawatirkan karena mengakibatkan komplikasi masalah kesehatan pada berbagai organ termasuk organ reproduksi pria. Infertilitas pada pria yang disebabkan oleh inflamasi kronik dan kematian sel yang terjadi pada sindrom metabolik erat kaitannya dengan peran TNF-α sebagai mediator inflamasi. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak etanolik daun kelor terhadap ekspresi TNF-α pada jaringan testis tikus Wistar model sindrom metabolik. Metode: Penelitian bersifat ekperimental laboratorik dengan rancangan penelitian posttest only control group design. Subjek tikus Wistar dibagi menjadi 5 kelompok dengan masing-masing kelompok berisi 6 tikus, KI sebagai kontrol normal, KII sebagai kelompok induksi sindrom metabolik, dan KIII, KIV, KV sebagai kelompok sindrom metabolik yang diberi ekstrak etanolik daun kelor dengan dosis secara berurutan 150 mg/kgBB, 250 mg/kgBB, dan 350 mg/kgBB. Induksi sindrom metabolik menggunakan pakan tinggi lemak dan STZ-NA. Perhitungan ekspresi TNF-α menggunakan metode semikuantitatif IDS. Analisis ekspresi TNF-α menggunakan uji One-Way ANOVA yang dilanjutkan post hoc LSD dan uji regresi linear. Hasil: Uji One-Way ANOVA ekspresi TNF-α pada jaringan testis menunjukkan p=0,001 (p<0,05), maka terdapat perbedaan ekspresi TNF-α yang signifikan pada kelima kelompok. Perbedaan bermakna terdapat pada KI terhadap KII dan KII terhadap KIV dan KV. Uji regresi linear menunjukkan pengaruh dosis ekstrak etanolik daun kelor memberikan arah negatif terhadap ekspresi TNF-α. Simpulan: Pemberian ekstrak etanolik daun kelor (Moringa oleifera, Lam) dengan dosis 150 mg/kgBB, 250 mg/kgBB, dan 350 mg/kgBB dapat menurunkan ekspresi TNF-α. Kata Kunci: TNF-α, Ekstrak Etanolik Daun Kelor, Sindrom Metabolik, Testis, Spermatogenesis
Senile osteoporosis that happens in menopause women has become threat to many as it appears to be asymptomatic.Calcium as the main specific nutrition that can compensate the imbalance cycle of bone resorption, help achieving an optimal bone mass, and prevent senile osteoporosis. Lack of adequate knowledge about senile osteoporosis and the urgency of fulfilling calcium daily intake has promote the increase incidence of senile osteoporosis. The purpose of this research is to study the knowledge about the role of calcium intake in preventing senile osteoporosis and the good way to educate others about the disease. The method being used is a qualitative and descriptive method with literature reviewing as its main sources of information. The result of this research is fulfilling a daily intake of calcium is indeed important as it helps compensate the increase of bone resorption and the education of this disease has to be done in an interesting and simple way as to make sure that others will understand fully about the information that has already been given.Senile osteoporosis prevention can vary but the most important way is to fulfill the daily needs of calcium and to increase people knowledge about the prevention and treatments of the disease.
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