SARS (Severe Acute Respiratory Syndrome Coronavirus)-CV-2 (2019-nCov), which showed up in China in December 2019 and spread all over the world, has becomed a serious health problem. An effective, safe and proven treatment has not yet been found. Chloroquine has been recommended by some authors to be used for the treatment of patients infected with this virus however chloroquine may have side effects and drug resistance problems. Artesunate is a semisynthetic derivative of artemisinin, an antimalarial drug. Artesunate was thought to be an effective treatment for covid-19 because of its anti-inflammatory activity, NF-κB (nuclear Factor kappa B)-coronavirus effect and chloroquine-like endocytosis inhibition mechanism.
Calcifying odontogenic cyst (COC) is a benign, locally aggressive, slow-growing lesion. Its occurrence constitutes about 2% of all odontogenic cysts. The most frequent sign is painless, slow growing swelling. Radiographically it appears as a well-defined unilocular radiolucency. The microscopical features of lesion showed well-delineated cystic proliferation of odontogenic epithelium with ghost cells and fibrous connective tissue wall. In the present study, 42 years old man who has COC associated with the impacted third molar treated with enucleation is reported after 6 months follow-up.
Artesunate
is a safe noncytotoxic drug with low side effects which is used in
the treatment of chloroquine-resistant malaria. In addition to being
an antimalarial drug, artesunate also has immunomodulatory, anticarcinogenic,
and antiviral activity. There are in vivo and in vitro studies reporting
that artesunate may have a positive effect on the treatment of COVID-19.
Artesunate may be effective based on its effect on the anti-inflammatory
activity, chloroquine-like endocytosis inhibition mechanism, and nuclear
factor kappa B (NF-κB) signal pathway. Severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) may cause neurological complications
in addition to targeting the respiratory system. In this study, we
have discussed the possible neuroprotective action mechanisms of artesunate.
We think that systemic and intranasal topical artesunate administration
may have a positive effect on neurological complications resulting
from COVID-19.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.