Probiotics have been used to treat gastrointestinal disorders. However, the effect of orally intubated probiotics on oral disease remains unclear. We assessed the potential of oral administration of Lactobacillus gasseri SBT2055 (LG2055) for Porphyromonas gingivalis infection. LG2055 treatment significantly reduced alveolar bone loss, detachment and disorganization of the periodontal ligament, and bacterial colonization by subsequent P. gingivalis challenge. Furthermore, the expression and secretion of TNF-α and IL-6 in gingival tissue was significantly decreased in LG2055-administered mice after bacterial infection. Conversely, mouse β-defensin-14 (mBD-14) mRNA and its peptide products were significantly increased in distant mucosal components as well as the intestinal tract to which LG2055 was introduced. Moreover, IL-1β and TNF-α production from THP-1 monocytes stimulated with P. gingivalis antigen was significantly reduced by the addition of human β-defensin-3. These results suggest that gastrically administered LG2055 can enhance immunoregulation followed by periodontitis prevention in oral mucosa via the gut immune system; i.e., the possibility of homing in innate immunity.
Phase-randomized light is one of the key assumptions in the security proof of the Bennett-Brassard 1984 (BB84) quantum-key-distribution (QKD) protocol using an attenuated laser. Though the assumption has been believed to be satisfied for conventional systems, it should be reexamined for current high-speed QKD systems. The phase correlation may be induced by the overlap of the optical pulses, the interval of which decreases as the clock frequency increases. The phase randomness was investigated experimentally by measuring the visibility of interference. An asymmetric Mach-Zehnder interferometer was used to observe the interference between adjacent pulses from a gain-switched distributed feedback laser diode driven at 10 GHz. Low visibility was observed when the minimum drive current was set far below the threshold, while interference emerged when the minimum drive current was close to the threshold. The theoretical evaluation on the impact of the imperfect phase randomization provides target values for the visibility to guarantee the phase randomness. The experimental and theoretical results show that secure implementation of decoy BB84 protocol is achievable even for the 10-GHz clock frequency by using the laser diode under proper operating conditions.
A new type of electronic interaction which couples two angular momenta, i.e. the angular momentum of a localized 4f system (J) and an orbital angular momentum generated in a cyclic π conjugated system by irradiation with a circularly-polarized light, has been identified in a lanthanide single molecule magnet.
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