Background: There are no reliable non-invasive markers of restenosis after percutaneous transluminal coronary angioplasty (PTCA). The aim of our study was to measure changes in QT interval dispersion after PTCA and to determine whether restenosis subsequently affects QT interval dispersion. Methods and Results: Fifty-six consecutive patients – 41 men and 15 women (mean age: 56.2 ±8.3 years) – with isolated stenosis of the left anterior descending artery who underwent successful PTCA were studied. A symptom-limited treadmill exercise test was performed within 7 days after PTCA and then again before repeated angiography. Repeated coronary angiography revealed restenosis in 15 patients (26.8%) and no signs of significant stenosis in 41 patients (73.2%). QT interval dispersion in the group of patients with restenosis measured before exercise increased from baseline 34 ± 7 to 49 ± 15 ms after 6 months (p < 0.01) and QT interval dispersion measured immediately after exercise increased from baseline 38 ± 4 to 68 ± 21 ms after 6 months (p < 0.001). In contrast, patients without restenosis showed no significant changes in QT interval dispersion measured before (baseline: 34 ± 9 ms; after 6 months 33 ± 12 ms; p = NS) and immediately after exercise (baseline: 34 ± 12 ms; after 6 months: 33 ± 10; p = NS). When QT interval dispersion ≧60 ms (measured 6 months after PTCA procedure) was considered as a potential marker of restenosis, this indicator had very high sensitivity and specificity when measured immediately after exercise (80 and 95% respectively). Conclusions: QT interval dispersion significantly increases in the group of patients with documented restenosis and may be a simple, non-invasive marker of restenosis. However, further studies are needed to confirm this observation.
STA may be sucsessfully used in patients with large LV aneurism for identification pts with high risk of life threatening ventricular arrythmias. P45/10260A new algorythm for identification patiens with a high risk of life threatening arrhythmias in different heart deseases based on the standart spectral-turbulence analysis of signal averaging ECG 0. Bockeria. Laboratory of Electrophysiology, Scienttjk Center Cardiovascular Surge, Moscow, Russian Federation Purpose: To create an algorithm based on spectral-turbulence analysis of signal averaging ECG (SAECG) for the evaluation of the degree of electrical instability of myocardium in patients (pts) with different heart diseases to find a new predictors of life threatening arrhythmias.Material and Methods: There were 145 pts in the study: 70 pts with coronary heart disease (CHD), 50 pts with nonischemic cardiomyopathia (NCMP), 25 healthy subjects. All the pts were observed by standard protocol (12-lead ECG, 24-hour monitoring of ECG, ECHO, tread-mil test, SAECG, heart rate variability (HRV)), heart catheterisation and EPS. We proposed a hypothesis that them were special zones (groups of cells) of impulse generation -zones of generation (ZG) with their own electrical properties like amplitude, velocity, frequency of generating impulse. They were calculated in different leads, using our own algorithm and also the total quantity of those ZG in the heart (21 parameters at all). The presence of 5 pathologic parameters were accept as a marker of electrical instability of myocardium.Results: There were from 10 to 12 ZG in the healthy subjects The quantity of high and low frequencies ZG were equal. In the group of patients with CHD and VT the quantity of ZG was 2 times high with the prevalence of high frequency ZG. In pts with NCMP the quantity of these zones was lower (both in high and low frequency ZG). We find out that the positive predictive value of our new algorithm was 60% and 57% in group with CHD and NCMP respectively and the diagnostic value was 85% and 80% respectively. Conclusion:The new algorithm may be useful in identification of the pts with high risk of VT and high grade ventricular premature beats. P46/10200Does the heart failure influence heart rate variability in patients with acute myocardial infarction treated with thrombolysis We found that time domain indexes of HRV are higher in group I than in group II at day 12 of hospitalisation.There is statistical significant difference between groups in SDNN, SDNNI and pNN50. There is not statistical significance at 6 month of follow-up.Conclusion: Low left ventricle ejection fraction (EF f 40%) influence the time domain indexes of HRV in patients with acute myocardial infarction treated with thrombolysis. P47/9957Efficacy of biventricular detection and treatment of ventricular arrhythmias: Preliiinary observations in heart failure patients While much is known concerning the hemodynamic effects of biventricular (BV) pacing, little has been reported concerning the efficacy of BV sensing and pacing in the detect...
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