a b s t r a c tCollaborative consumption is an emerging socio-economic model based on sharing, renting, gifting, bartering, swapping, lending and borrowing. Made possible through community interaction and, increasingly, use of network technologies, these alternative and more sustainable ways of consuming have attracted growing attention for their potential to prevent new purchases, intensify the use of idle assets and promote reuse of possessions that are no longer wanted. Nonetheless, the uptake of ProductService Systems (PSSs) that enable collaborative consumption is still very limited. This paper investigates how consumers' values can influence the acceptance, adoption and diffusion of collaborative consumption. It reviews two theoretical frameworks used to understand pro-environmental behaviour, social psychological models of behaviour and social practice theory. Coming from contrasting disciplinary perspectives, these approaches conceptualise values differently. The paper evaluates the possibility of resolving these differences through a mixed methods study. It examines values empirically through a case study of Ecomodo, a UK-based online marketplace where people can lend and borrow each other's objects, spaces and skills, and present the results of a quantitative study which identified and measured value priorities among Ecomodo users through Schwartz's Portrait Value Questionnaire. It concludes with a discussion of the role of values in relation to the introduction and scaling up of PSSs that enable collaborative consumption.
Purpose-This paper aims to investigate consumers' perspectives on sustainable clothing consumption and to examine ways in which this information could influence retailers' policies. Design/methodology/approach-Qualitative research was conducted using focus groups, home tasks and workshops with 99 participants. The sample represented different groups of consumers in relation to their sustainability behaviour. Findings-Focus group participants had a limited awareness of the sustainability impacts of clothing. Where participants displayed pro-environmental behaviour, this was not necessarily intentional, but was largely a response to other influences. The respondents' maintenance and disposal of clothes were found to be influenced mainly by existing habits and routines, which usually take precedence over awareness of sustainable practice. The research indicated that consumers could be persuaded to change their behaviour in relation to sustainability by being encouraged and enabled to reflect more on their behaviour. Research limitations/implications-This study uses qualitative research and is limited to UK consumers. Future research in this field could incorporate quantitative methods or in-depth interviews. Academics could conduct further research and generate theories which apply to the sustainable consumption of clothing. Social implications-The findings have implications for retailers, academics and society. Retailers can develop and implement more sustainable policies and practices in relation to clothing production and consumption. There are wider implications for society and the environment in that retailers' practices can impact greatly on the sustainability of the planet's resources. Originality/value-This paper's originality lies in its assessment of the implications for retailers of consumers' views on the sustainable consumption of clothing.
This paper describes recent research conducted at Sheffield Hallam
Predictive preventive personalized medicine Liver cancer is the fifth most common form of cancer worldwide [1], with an incidence rate almost equals the mortality rate and ranks 3 rd among causes of cancer related death [2]. The coexistence of two life threatening conditions, cancer and liver cirrhosis makes the staging challenging. However, there are some staging systems, e.g. the Barcelona staging system for Hepatocellular carcinoma (HCC) [3], that suggest treatment options and management. Whereas diagnosis in early stages gives hope for a curative outcome, the treatment regime for around 80 % [2] of the patients classified as severe stages only gears towards palliation [4]. An intra-arterial radiation approach, radioembolisation (RE) is ubiquitously applied as one of palliative approaches. Although, in general RE shows promising results in intermediate and advanced stage HCC [5], individual treatment outcomes are currently unpredictable. Corresponding stratification criteria are still unclear. We hypothesised that individual radioresistance/radiosensitivity may play a crucial role in treatment response towards RE strongly influencing individual outcomes. Further, HCC represents a highly heterogeneous group of patients which requires patient stratification according to clear criteria for treatment algorithms to be applied individually. Multilevel diagnostic approach (MLDA) is considered helpful to set-up optimal predictive and prognostic biomarker panel for individualised application of radioembolisation. Besides comprehensive medical imaging, our MLDA includes non-invasive multi-omics and sub-cellular imaging. Individual patient profiles are expected to give a clue to targeting shifted molecular pathways, individual RE susceptibility, treatment response. Hence, a dysregulation of the detoxification pathway (SOD2/Catalase) might indicate possible adverse effects of RE, and highly increased systemic activities of matrix metalloproteinases indicate an enhanced tumour aggressiveness and provide insights into molecular mechanisms/targets. Consequently, an optimal set-up of predictive and prognostic biomarker panels may lead to the changed treatment paradigm from untargeted "treat and wait" to the cost-effective predictive, preventive and personalised approach, improving the life quality and life expectancy of HCC patients. Keywords: Market access, Value, Strategy, Companion diagnostics, Cost-effectiveness, Reimbursement, Health technology assessment, Economic models, Predictive preventive personalized medicine Achieving and sustaining seamless "drug -companion diagnostic" market access requires a sound strategy throughout a product life cycle, which enables timely creation, substantiation and communication of value to key stakeholders [1, 2]. The study aims at understanding the root-cause of market access inefficiencies of companies by gazing at the "Rx-CDx" co-development process through the prism of "value", and developing a perfect co-development scenario based on the literature review and discussions with the ...
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