In this report, we
present double-hydrophilic block glycopolymers
of poly(2-hydroxyethyl methacrylate)-b-poly(2-(β-glucosyloxy)ethyl
methacrylate) (PHEMA-b-PGEMA) and amphiphilic block
glycopolymers of poly(ethyl methacrylate)-b-PGEMA
(PEMA-b-PGEMA) synthesized via reversible addition–fragmentation
chain transfer (RAFT) polymerization. The block glycopolymers were
prepared in two compositions of P(H)EMA macro-chain transfer agents
(CTAs) and similar molecular weights of PGEMA. Structural analysis
of the resulting polymers as well as the conversion of (H)EMA and
GEMA monomers were determined by 1H NMR spectroscopy. Size
exclusion chromatography measurements confirmed both P(H)EMA macro-CTAs
and block glycopolymers had a low dispersity (Đ ≤ 1.5). The synthesized block glycopolymers had
a degree of polymerization and a molecular weight up to 222 and 45.3
kg mol–1, respectively. Both block glycopolymers
self-assembled into micellar structures in aqueous solutions as characterized
by fluorescence spectroscopy, ultraviolet–visible spectroscopy,
and dynamic light scattering experiments.
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