The
hydroformylation reaction is one of the most intensively explored
reactions in the field of homogeneous transition metal catalysis,
and many industrial applications are known. However, this atom economical
reaction has not been used to its full potential, as many selectivity
issues have not been solved. Traditionally, the selectivity is controlled
by the ligand that is coordinated to the active metal center. Recently,
supramolecular strategies have been demonstrated to provide powerful
complementary tools to control activity and selectivity in hydroformylation
reactions. In this review, we will highlight these supramolecular
strategies. We have organized this paper in sections in which we describe
the use of supramolecular bidentate ligands, substrate preorganization
by interactions between the substrate and functional groups of the
ligands, and hydroformylation catalysis in molecular cages.
Phosphinidenes [R-P] are convenient P building blocks for the synthesis of a plethora of organophosphorus compounds. Thus far, transition-metal-complexed phosphinidenes have been used for their singlet ground-state reactivity to promote selective addition and insertion reactions. One disadvantage of this approach is that after transfer of the P moiety to the substrate, a challenging demetallation step is required to provide the free phosphine. We report a simple method that enables the Lewis acid promoted transfer of phenylphosphinidene, [PhP], from NHC=PPh adducts (NHC=N-heterocyclic carbene) to various substrates to produce directly uncoordinated phosphorus heterocycles that are difficult to obtain otherwise.
Syntheses, properties, and reactivity of N‐heterocyclic carbene–phosphinidene adducts are reviewed. These adducts, formally built by combining a phosphinidene with a carbene, are characterized by high nucleophilicity at the phosphorus atom. The main types of reactivity these adducts exhibit are: Lewis‐base reactivity towards main group and organic compounds as well as transition‐metal complexes, substitution reactions at the phosphorus atom with main group compounds and transition‐metal complexes, and phosphinidene transfer reactions resulting in C–P bond cleavage. These differ substantially from the classic phosphaalkenes.
This
study describes the development and understanding of a palladium-catalyzed
cross-coupling of fluoroacetamides with boronic acids, under base-free
conditions, to selectively give valuable α,α-difluoroketone
derivatives. Detailed mechanistic studies were conducted to assess
the feasibility of each elementary step, that is, C(acyl)–N
bond oxidative addition, followed by base-free transmetallation and
reductive elimination. These investigations allowed the structural
characterization of palladium(II)fluoroacyl intermediates derived
from C–N bond oxidative addition of an amide electrophile.
They also revealed the high reactivity of these intermediates for
transmetallation with boronic acids without exogenous base. The mechanistic
studies also provided a platform to design a practical catalytic protocol
for the synthesis of a diversity of α,α-difluoroketones,
including CF2H–ketones. Finally, the synthetic potential
of this fluoroacylation methodology is highlighted in sequential,
orthogonal C–Br and C–N bond functionalization of an
α-bromo-α,α-difluoroacetamide with a focus on compounds
of potential biological relevance.
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