We read with interest the article by Zimmerer et al. [1] on the clinical and treatment aspects of spinal epidural abscess (SEA). At the outset we would like to congratulate the authors on the thorough and concise review of this uncommon condition.As noted by the authors, SEA is found in 0.2-2.8 cases per 10,000 hospital admissions, thus, requiring a high degree of clinical suspicion in their diagnosis [2]. Further as seen in the study, patients oftentimes present with nonspecific back pain thus making the diagnosis difficult. The severity and the location of weakness depend on the location of the abscess; with the most common site being thoracolumbar region [3]. MRI spine with and without (wwo) contrast is the diagnostic modality of choice with all patients in the study being diagnosed by it [1].However in early stages of SEA, MRI can remain inconclusive [4] and due to spinal shock, patient can be hyporeflexic and a sensory level might not yet have been formed. Thus, a thoraco-lumbar SEA can clinically mimic Guillain-Barre syndrome (GBS). We report the case of a 69-year-old male who was transferred from an outside facility with low back pain and progressive ascending weakness since 2 days. An MRI of the thoracolumbar spine wwo contrast done at the onset of symptoms was noncontributory. Upon admission he was paraplegic with absent knee and ankle reflexes, plantar responses were mute and a sensory level could not be established. He had urinary retention. He was afebrile but confounding the picture, he had a bowel perforation, which required emergent surgical repair. The elevated CRP of 325 and white blood cell count of 17,600 cells/ll was attributed to bowel perforation and fecal peritonitis. Based on the clinical and radiological findings, a working diagnosis of GBS was made. To further confirm this, a bedside lumbar puncture (LP) was attempted 4 days after the initial onset of the symptoms, which did not yield any fluid. A fluoroscopic guided LP done at the L1-L2 level provided 5 ml yellowish fluid with a protein of 3,295 mg, RBC of 888 cells/ll and a normal corrected WBC consistent with a cervico-thoracic spinal block or Froin's syndrome. Repeat emergent MRI wwo of the entire spine showed extensive cervicothoracic epidural abscess with infarction of the thoracic cord. Patient underwent emergent open decompression and drainage of the abscess. Similar to the author's study, where Staphylococcus aureus (S. aureus) was the most common pathogen isolated, the abscess revealed S. aureus [1].It is interesting to note that study had four patients with primary SEAs and three with secondary SEAs where an oral focus was thought to be the cause, although only one of the primary SEAs had similar pathogen as the oral one [1]. The only concern is whether a thorough search was made to identify other foci of infection. In our own case, we initially thought the bowel perforation as the source of infection but upon a more careful physical examination, patient had otitis externa, which we believe was the source of infection based o...
There are two major causes of disability in patients with Parkinson disease: motor fluctuations that occur when a dose of levodopa becomes ineffective, leading to a "wearing off," and hyperkinetic movements (dyskinesias) caused by excessive levels of dopamine. The utility of continuous levodopa treatment is therefore limited by motor complications. Pharmacologic options to treat wearing off include adding (or increasing the dosage of) levodopa, adding (or increasing the dosage of) a dopamine agonist, or adjunctive treatment with a monoamine oxidase inhibitor or catechol-O-methyltransferase inhibitor. Dyskinesias will respond to a reduction in levodopa dosage at the expense of worsening parkinsonism and an increase in the number of "off" episodes. Continuous dopamine stimulation may overcome the pulsatile stimulation of postsynaptic dopamine receptors produced by standard oral formulations of levodopa that lead to motor complications.
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