The initial stage of fiber structure development in the continuous neck-drawing of amorphous poly(ethylene terephthalate) fibers was analyzed by in-situ wide-angle x-ray diffraction, small-angle x-ray scattering, and temperature measurements. The time error of the measurements (< 600 μs) was obtained by synchrotron x-ray source and laser irradiation heating. A highly ordered fibrillar-shaped two-dimensional (smectic-like) structure was found to be formed less than 1 ms after necking. By analyzing its (001') and (002') diffractions, the length of the structure 60-70 nm were obtained. A three-dimensionally ordered triclinic crystal began to form with the vanishing of the structure around 1 ms after necking. The amount and size of the crystal were almost saturated within several milliseconds of necking, during which time a mainly exothermic heat of crystallization was also observed.

Poly(ethylene terephthalate) (PET) fiber was heated by carbon dioxide laser radiation during the continuous drawing process. Numerical calculation shows that the PET fiber can be heated much more rapidly and uniformly by heat radiation than by convective heat transfer through the fiber surface. During CO2 laser heated drawing, temperature in the vicinity of a neck-like deformation can be measured on-line with high precision, because the neck-like deformation is located within a range of 0.5 mm. We measured the fiber temperature profiles on the drawing process by IR thermometer that has a range resolution of 0.355 mm. The temperature at which neck-like deformation of the fiber initiates is higher than Tg when draw ratio is less than 4.5, but lower than Tg when draw ratio is more than 5.5. The maximum fiber temperature in the drawing process increases with draw ratio, up to 208°C for a draw ratio of 6.0. The rate of orientation-induced crystallization in the drawing process was estimated by comparison of measured temperature profiles with calculated temperature profiles.

ObjectivesTo clarify the association between glucose intolerance and high altitudes (2900–4800 m) in a hypoxic environment in Tibetan highlanders and to verify the hypothesis that high altitude dwelling increases vulnerability to diabetes mellitus (DM) accelerated by lifestyle change or ageing.DesignCross-sectional epidemiological study on Tibetan highlanders.ParticipantsWe enrolled 1258 participants aged 40–87 years. The rural population comprised farmers in Domkhar (altitude 2900–3800 m) and nomads in Haiyan (3000–3100 m), Ryuho (4400 m) and Changthang (4300–4800 m). Urban area participants were from Leh (3300 m) and Jiegu (3700 m).Main outcome measureParticipants were classified into six glucose tolerance-based groups: DM, intermediate hyperglycaemia (IHG), normoglycaemia (NG), fasting DM, fasting IHG and fasting NG. Prevalence of glucose intolerance was compared in farmers, nomads and urban dwellers. Effects of dwelling at high altitude or hypoxia on glucose intolerance were analysed with the confounding factors of age, sex, obesity, lipids, haemoglobin, hypertension and lifestyle, using multiple logistic regression.ResultsThe prevalence of DM (fasting DM)/IHG (fasting IHG) was 8.9% (6.5%)/25.1% (12.7%), respectively, in all participants. This prevalence was higher in urban dwellers (9.5% (7.1%)/28.5% (11.7%)) and in farmers (8.5% (6.1%)/28.5% (18.3%)) compared with nomads (8.2% (5.7%)/15.7% (9.7%)) (p=0.0140/0.0001). Dwelling at high altitude was significantly associated with fasting IHG+fasting DM/fasting DM (ORs for >4500 and 3500–4499 m were 3.59/4.36 and 2.07/1.76 vs <3500 m, respectively). After adjusting for lifestyle change, hypoxaemia and polycythaemia were closely associated with glucose intolerance.ConclusionsSocioeconomic factors, hypoxaemia and the effects of altitudes >3500 m play a major role in the high prevalence of glucose intolerance in highlanders. Tibetan highlanders may be vulnerable to glucose intolerance, with polycythaemia as a sign of poor hypoxic adaptation, accelerated by lifestyle change and ageing.

Fiber structure development in the poly(ethylene terephthalate) fiber drawing process was investigated by on-line measurement of wide-angle and small-angle x-ray scattering employing both a high-luminance x-ray source and a carbon dioxide laser-heated-drawing system. Intensity profile of transmitted x-ray confirmed the location of the neck-drawing point. Obtained diffraction images had a time-resolution of several milliseconds, which still leaves a great capacity for improvement. Crystal diffraction appeared in the wide-angle x-ray images almost instantaneously about 20 ms after necking, whereas a four-point SAXS pattern appeared immediately after necking. With the elapse of time after necking, the four-point scattering pattern changed to a meridional two-point shape.

ObjectivePrevalence of hypertension was examined in a widely dispersed (45 110 km2) representative group of Ladakhi in Northern India. The influence of hypoxic environment of wide-ranged altitude (2600–4900 m) and lifestyle change on hypertension was studied.Methods2800 participants (age 20–94 years) were enrolled. Systolic blood pressure ≥140 mm Hg and/or diastolic blood pressure of ≥90 mm Hg and/or taking current anti-hypertensive medicine was defined as hypertension. Height and weight for body mass index and SpO2 were examined. The rural population comprised six subdivisions with a distinct altitude, dietary and occupational pattern. Participants in the urban area of Leh consist of two groups, that is, migrants settled in Leh from the Changthang nomadic area, and dwellers born in Leh. The prevalence of hypertension in the two groups was compared with that in the farmers and nomads in rural areas. The effects of ageing, hypoxia, dwelling at high altitude, obesity, modernised occupation, dwelling in an urban area, and rural-to-urban migration to hypertension were analysed by multiple logistic regression.ResultsThe prevalence of hypertension was 37.0% in all participants and highest in migrants settled in Leh (48.3%), followed by dwellers born in Leh town (41.1%) compared with those in rural areas (33.5). The prevalence of hypertension in nomads (all: 27.7%, Tibetan/Ladakhi: 19.7/31.9%)) living at higher altitude (4000–4900 m) was relatively low. The associated factors with hypertension were ageing, overweight, dwelling at higher altitude, engagement in modernised sedentary occupations, dwelling in urban areas, and rural-to-urban migration. The effects of lifestyle change and dwelling at high altitude were independently associated with hypertension by multivariate analysis adjusted with confounding factors.ConclusionsSocioeconomic and cultural factors play a big role with the effect of high altitude itself on high prevalence of hypertension in highlanders in Ladakh.