The 1990s have seen a rapid growth of research interests in mobile ad hoc networking. The infrastructureless and the dynamic nature of these networks demands new set of networking strategies to be implemented in order to provide efficient end-to-end communication. This, along with the diverse application of these networks in many different scenarios such as battlefield and disaster recovery, have seen MANETs being researched by many different organisations and institutes. MANETs employ the traditional TCP/IP structure to provide end-to-end communication between nodes. However, due to their mobility and the limited resource in wireless networks, each layer in the TCP/IP model require redefinition or modifications to function efficiently in MANETs. One interesting research area in MANET is routing. Routing in the MANETs is a challenging task and has received a tremendous amount of attention from researches. This has led to development of many different routing protocols for MANETs, and each author of each proposed protocol argues that the strategy proposed provides an improvement over a number of different strategies considered in the literature for a given network scenario. Therefore, it is quite difficult to determine which protocols may perform best under a number of different network scenarios, such as increasing node density and traffic. In this paper, we provide an overview of a wide range of routing protocols proposed in the literature. We also provide a performance comparison of all routing protocols and suggest which protocols may perform best in large networks. AbstractThe 1990s have seen a rapid growth of research interests in mobile ad hoc networking. The infrastructureless and the

Abstract-Over the past several years, there has been a renewed interest in complex orthogonal designs for their application in space-time block coding. Motivated by the success of this application, this paper generalizes the definition of complex orthogonal designs by introducing orthogonal designs over the quaternion domain. This paper builds a theory of these novel quaternion orthogonal designs, offers examples, and provides several construction techniques. These theoretical results, along with the results of preliminary simulations, lay the foundation for developing applications of these designs as orthogonal space-time-polarization block codes.

Limitations of antiretroviral therapy (ART) include poor patient adherence, drug toxicities, viral resistance, and failure to penetrate viral reservoirs. Recent developments in nanoformulated ART (nanoART) could overcome such limitations. To this end, we now report a novel effect of nanoART that facilitates drug depots within intracellular compartments at or adjacent to the sites of the viral replication cycle. Poloxamer 407-coated nanocrystals containing the protease inhibitor atazanavir (ATV) were prepared by high-pressure homogenization. These drug particles readily accumulated in human monocyte-derived macrophages (MDM). NanoATV concentrations were ϳ1,000 times higher in cells than those that could be achieved by the native drug. ATV particles in late and recycling endosome compartments were seen following pulldown by immunoaffinity chromatography with Rab-specific antibodies conjugated to magnetic beads. Confocal microscopy provided cross validation by immunofluorescent staining of the compartments. Mathematical modeling validated drug-endosomal interactions. Measures of reverse transcriptase activity and HIV-1 p24 levels in culture media and cells showed that such endosomal drug concentrations enhanced antiviral responses up to 1,000-fold. We conclude that late and recycling endosomes can serve as depots for nanoATV. The colocalization of nano-ATV at endosomal sites of viral assembly and its slow release sped antiretroviral activities. Long-acting nanoART can serve as a drug carrier in both cells and subcellular compartments and, as such, can facilitate viral clearance. IMPORTANCEThe need for long-acting ART is significant and highlighted by limitations in drug access, toxicity, adherence, and reservoir penetrance. We propose that targeting nanoformulated drugs to infected tissues, cells, and subcellular sites of viral replication may improve clinical outcomes. Endosomes are sites for human immunodeficiency virus assembly, and increasing ART concentrations in such sites enhances viral clearance. The current work uncovers a new mechanism by which nanoART can enhance viral clearance over native drug formulations.

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Modern communications systems are heavily reliant on statistical techniques to recover information in the presence of noise and interference. One of the mathematical structures used to achieve this goal is Hadamard matrices. They are used in many different ways and some examples are given. This paper concentrates on code division multiple access systems where Hadamard matrices are used for user separation. Two older techniques from design and analysis of experiments which rely on similar processes are also included. We give a short bibliography (from the thousands produced by a google search) of applications of Hadamard matrices appearing since the paper of Hedayat and Wallis in 1978 and some applications in telecommunications. Disciplines Physical Sciences and Mathematics Publication DetailsThis article was originally published as Seberry, J, Wysocki, Bj and Wysocki, TA, On some applications of Hadamard matrices, Metrika, 62, (2005) Abstract Modern communications systems are heavily reliant on statistical techniques to recover information in the presence of noise and interference. One of the mathematical structures used to achieve this goal is Hadamard matrices. They are used in many different ways and some examples are given. This paper concentrates on code division multiple access systems where Hadamard matrices are used for user separation. Two older techniques from design and analysis of experiments which rely on similar processes are also included. We give a short bibliography (from the thousands produced by a google search) of applications of Hadamard matrices appearing since the paper of Hedayat and Wallis in 1978 and some applications in telecommunications.