Chalcones are aromatic ketones which forms a central core for various important biological active compounds. A series of chalcones were prepared by Claisen-Schmidt condensation of appropriate aromatic aldehydes with actophenones in the presence of nano copper ferrite in ethanol. All the synthesized compounds have been characterized by FT-IR, 1 H-NMR and MASS spectroscopy. The synthesized compounds are screened for their biological activities against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus subtilis using cup plate method and disc diffusion method.
Iron titanate nanoparticles (FeTiO3-NPs, TiFe-0.5, TiFe-1.0, TiFe-2.0 with fixed and variable
compositions of Fe and Ti, respectively) were synthesized under ultrasonication and characterized
using XRD, FESEM-EDAX and UV-vis DRS spectral techniques. The XRD analysis has clearly
indicated the characteristic peaks in the nanoparticles. The morphologies have shown the spherical
shaped particles and in the EDAX analysis, the respective elements (Fe, Ti, O) in the prepared
nanoparticles were identified. Similarly, the absorption maxima of the nanoparticles have increased
with increase in the Ti content between 380-570 nm. Using these nanoparticles,
cyclohepta[d]pyrimidine-2(5H)-thione derivatives (4a-e) were synthesized through one-pot approach
with cycloheptanone (1), some substituted benzaldehyes (2a-e) and thiourea (3) as the precursors, which
was performed under the guidelines of green chemistry. The progress of the reactions were monitored
by TLC and the formed derivatives were characterized by using 1H NMR, FTIR and Mass spectral
techniques along with the determination of their melting points. The NPs were magnetically separable
and with its recycled forms, the reaction was conducted in 3 consecutive cycles and observed that the
% yields have not varied much. The antibacterial activity studies were conducted against Gram-negative
Escherichia coli, Klebsiella pneumonia, Gram-positive Staphylococcus aurues, Bacillus Subtilis bacteria
with the derivatives (4a-e). In these studies, almost all the derivatives have shown from moderate to
better antibacterial activity.
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