Tokamak discharges with improved energy confinement properties arising from internal transport barriers (ITBs) have certain attractive features, such as a large bootstrap current fraction, which suggest a potential route to the steady-state mode of operation desirable for fusion power plants. This paper first reviews the present state of theoretical and experimental knowledge regarding the formation and characteristics of ITBs in tokamaks. Specifically, the current status of theoretical modelling of ITBs is presented; then, an international ITB database based on experimental information extracted from some nine tokamaks is described and used to draw some general conclusions concerning the necessary conditions for ITBs to appear, comparing these with the theoretical models. The experimental situation regarding the steady-state, or at least quasi-steady-state, operation of tokamaks is reviewed and finally the issues and prospects for achieving such operational modes in ITER are discussed. More detailed information on the characteristics of ITBs in some 13 tokamaks (as well as helical devices) appears in the appendix.

Protected from host immune attack and antibiotic penetration by their unique cell envelope, mycobacterial pathogens cause devastating human diseases such as tuberculosis. Seamless coordination of cell growth with cell envelope elongation at the pole maintains this barrier. Unraveling this spatiotemporal regulation is a potential strategy for controlling mycobacterial infections. Our biochemical analysis previously revealed two functionally distinct membrane fractions in Mycobacterium smegmatis cell lysates: plasma membrane tightly associated with the cell wall (PM-CW) and a distinct fraction of pure membrane free of cell wall components (PMf). To provide further insight into the functions of these membrane fractions, we took the approach of comparative proteomics and identified more than 300 proteins specifically associated with the PMf, including essential enzymes involved in cell envelope synthesis such as a mannosyltransferase, Ppm1, and a galactosyltransferase, GlfT2. Furthermore, comparative lipidomics revealed the distinct lipid composition of the PMf, with specific association of key cell envelope biosynthetic precursors. Live-imaging fluorescence microscopy visualized the PMf as patches of membrane spatially distinct from the PM-CW and notably enriched in the pole of the growing cells. Taken together, our study provides the basis for assigning the PMf as a spatiotemporally distinct and metabolically active membrane domain involved in cell envelope biogenesis.

Characteristics of internal transport barrier (ITB) structure are studied and the active ITB control has been developed in JT-60U reversed shear plasmas. The following results are found. Outward propagation of the ITB with steep T i gradient is limited to the minimum safety factor location (ρ qmin). However the ITB with reduced T i gradient can move to the outside of ρ qmin. Lower boundary of ITB width is proportional to the ion poloidal gyroradius at the ITB center. Furthermore the demonstration of the active control of the ITB strength based on the modification of the radial electric field shear profile is successfully performed by the toroidal momentum injection in different directions or the increase of heating power by neutral beams.

This paper reports results on the progress in steady-state high-βp ELMy H-mode discharges in JT-60U. A fusion triple product, nD(0)τETi(0), of 3.1 × 1020 m−3 s keV under full non-inductive current drive has been achieved at Ip = 1.8 MA, which extends the record value of the fusion triple product under full non-inductive current drive by 50%. A high-beta plasma with βN ∼ 2.7 has been sustained for 7.4 s (∼60τE), with the duration determined only by the facility limits, such as the capability of the poloidal field coils and the upper limit on the duration of injection of neutral beams. Destabilization of neoclassical tearing modes (NTMs) has been avoided with good reproducibility by tailoring the current and pressure profiles. On the other hand, a real-time NTM stabilization system has been developed where detection of the centre of the magnetic island and optimization of the injection angle of the electron cyclotron wave are done in real time. By applying this system, a 3/2 NTM has been completely stabilized in a high-beta region (βp ∼ 1.2, βN ∼ 1.5), and the beta value and confinement enhancement factor have been improved by the stabilization.

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