The electrocatalytic activity of a 2,2,6,6-tetramethylpipridine-N-oxyl (TEMPO)-modified electrode toward the oxidation of carbohydrates in phosphate buffer solution was investigated under neutral aqueous solution conditions at 25 8C. The modified electrode was prepared on the surface of a glassy carbon electrode by the electrochemical polymerization of a TEMPO precursor containing a pyrrole side chain. Cyclic voltammetric studies showed that the anodic peak current increased with the concentration of carbohydrates in a dose-dependent manner.Keywords: TEMPO · Mediator · Electrocatalytic oxidation Many catalytic methods that utilize clean oxidants have been exploited from an environmental and atom-economical perspective [1,2]. Organic nitroxyl radicals are known to be an effective redox mediator for various types of oxidation reactions with organic compounds [3]. A number of groups have recently reported the development of efficient organic nitroxyl radical catalyzed reactions [4][5][6][7]. Minteer and co-workers reported a method to immobilize 2,2,6,6-tetramethylpipridine-N-oxyl (TEMPO) while simultaneously enhancing the electrocatalytic activity toward several alcohols and saccharides [8]. Before, we have reported the amperometric determination of optically active 1-phenylethanol using chiral nitroxyl radicalmodified polypyrrole films prepared by electrochemical polymerization [9]. However, no study has been reported on the electrocatalytic oxidation of carbohydrates in aqueous solution mediated by a TEMPO-modified electrode prepared by electrochemical polymerization. The electrochemical polymerization method is a simple and rapid process to produce a TEMPO-modified electrode in the form of a film adhered to an electrode surface that is expected to be applied to the electrocatalytic oxidation of various compounds [10][11][12].Herein, we demonstrate a TEMPO-modified electrode prepared on the surface of a glassy carbon (GC) electrode by electrochemical polymerization for the electrocatalytic oxidation of carbohydrates in a near neutral pH phosphate buffer solution at 25 8C.The electrocatalytic activity of the TEMPO-modified GC electrode was investigated to compare it with that of non-immobilized TEMPO in aqueous solution. The present system may be applicable to the early detection of diabetes; therefore, cyclic voltammograms (CVs) of the TEMPO-modified electrode in the presence of glucose were measured and are shown in Figure 1.The anodic peak current for glucose was significantly enhanced compared with that for the blank voltammogram (TEMPO-modified GC electrode itself), and the cathodic peak disappeared. This indicates that the TEM-PO-modified GC electrode is electrocatalytically active for the oxidation of glucose [13,14]. Furthermore, the anodic peak current was proportional to the glucose concentration, which suggests that this system may be Graduate School of Pharmaceutical Sciences, Tohoku University, Aramaki, Aoba-ku, Sendai 980-8578, Japan Fig. 1. CVs of the TEMPO-modified GC electrode in the ab...
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.