SUMMARY Androgen receptor (AR) signaling is a distinctive feature of prostate carcinoma (PC) and represents the major therapeutic target for treating metastatic prostate cancer (mPC). Though highly effective, AR antagonism can produce tumors that bypass a functional requirement for AR, often through neuroendocrine (NE) transdifferentiation. Through the molecular assessment of mPCs over two decades, we find a phenotypic shift has occurred in mPC with the emergence of an AR-null NE-null phenotype. These “double-negative” PCs are notable for elevated FGF and MAPK pathway activity, which can bypass AR dependence. Pharmacological inhibitors of MAPK or FGFR repressed the growth of double-negative PCs in vitro and in vivo. Our results indicate that FGF/MAPK blockade may be particularly efficacious against mPCs with an AR-null phenotype.

In the present study, silver nanoparticles (AgNPs) were synthesized in situ on orthodontic elastomeric modules (OEM) using silver nitrate salts as metal-ion precursors and extract of the plant Hetheroteca inuloides (H. inuloides) as bioreductant via a simple and eco-friendly method. The synthesized AgNPs were characterized by UV-visible spectroscopy; scanning electron microscopy-energy-dispersive spectroscopy (SEM-EDS) and transmission electron microscopy (TEM). The surface plasmon resonance peak found at 472 nm confirmed the formation of AgNPs. SEM and TEM images reveal that the particles are quasi-spherical. The EDS analysis of the AgNPs confirmed the presence of elemental silver. The antibacterial properties of OEM with AgNPs were evaluated against the clinical isolates Streptococcus mutans, Lactobacillus casei, Staphylococcus aureus and Escherichia coli using agar diffusion tests. The physical properties were evaluated by a universal testing machine. OEM with AgNPs had shown inhibition halos for all microorganisms in comparison with OEM control. Physical properties increased with respect to the control group. The results suggest the potential of the material to combat dental biofilm and in turn decrease the incidence of demineralization in dental enamel, ensuring their performance in patients with orthodontic treatment.

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Polymer concrete (PC) was developed by using different concentrations of silica sand as aggregate and a commercial unsaturated preaccelerated (orthophtalic) polyester resin. The PC specimens were submitted to gamma radiation at several dosages: 5, 10, 50, 100, and 150 kGy. Mechanical performance was evaluated including the compressive strength, the compressive strain at yield point, and the compression modulus of elasticity. As expected, mechanical properties depend on both the resin concentration and the applied radiation dose. Improvement achieved in mechanical properties is related to the morphological characteristics observed by scanning electron microscopy.

Polymeric fibers have been used since the 1980s for improvement of the concrete. However, high mechanical performance has been obtained at high cost and using complex technologies. At least two parameters are important here: dimensions and surface characteristics of the fibers. We have modified nylon 6,12 fiber surfaces by 5, 10, 50, and 100 kGy gamma irradiation dosages. Tensile strength of the irradiated fibers was determined and then the fibers mixed at 1.5%, 2.0%, and 2.5% in volume with Portland cement, gravel, sand, and water. The compressive strength of the fiber reinforced concrete (FRC) was evaluated and the results were compared with results for similar materials reported before. The highest values of the compressive strength of FRC are seen for fibers at 50 kGy and 2.0% in volume of fiber; the strength is 122.2 MPa, as compared to 35 MPa for simple concrete without fibers. We advance a mechanism by which the fiber structure can be affected by gamma irradiation resulting in the compressive strength improvement of the concrete.