A substance P antagonist inhibits vagally induced increase in vascular permeability and bronchial smooth muscle contraction in the guinea pig (vascular Communicated by U. S. von Euler, November 8, 1982 ABSTRACT Electrical stimulation of the cervical vagus nerve in anesthetized guinea pigs induced a rapid increase in respiratory insufflation pressure, suggesting increased airway resistance.

The effect of ingestion of amino acids (Vamin N), glucose, and fat (Intralipid) on the concentration of neurotensin-like immunoreactivity (NTLI) in plasma was determined in 6 healthy male volunteers. After ingestion of Intralipid (55 ml, 200 mgxml-1) there was a significant increase in the plasma concentration of NTLI. The calculated integrated total NTLI response (6.7 +/- 2.5 nM over 180 min) was statistically significant. Although isocaloric amounts of Vamin and glucose also increased the plasma concentration of NTLI, these increases were not statistically significant. The data indicate that fat is an important stimulus for the release of NTLI from the small intestine. It is suggested that neurotensin, or a metabolite, in blood may be a hormone involved in the postprandial inhibition of gastric motility and gastric acid secretion elicited from the small intestine.

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RENKIN, E. M. and S. ROSELL. The influence of sympathetic adrenergic vasoconstrictor nerves on transport of daffmible solutes jrom blood to tissues in skeletal muscle. Acta physiol. scand. 1962. 54. [223][224][225][226][227][228][229][230][231][232][233][234][235][236][237][238][239][240]. -Arteriovenous (A-V) extraction of rubidium -86 was continuously recorded in isolated skeletal muscles of dogs and cats perfused with blood at constant flow. In a few experiments, A-V extraction of oxygen was measured also. The sympathetic trunk, still connected to the muscle, was stimulated electrically under various conditions. Excitation of sympathetic adrenergic vasoconstrictor nerves produced an increase in vascular resistance and a decrease in RbsG and 0, transport. These effects were graded in relation to stimulus frequency, persistent throughout continued stimulation and large enough to be of importance at low, physiological frequencies. The changes in vascular resistance and blood-tissue transport are mechanically independent. Both are mediated by preganglionic fibers of similar properties, but it is not possible to tell if the same or different fibers are involved. The reduction in transport is considered to result mainly from restriction of the number of open capillaries, due to cIosure of precapillary sphincters, with some contribution from a decrease in the uniformity of circulation through those parts of the capillary network remaining open. 223 15-623015. Acta physiol. scand. VoZ. 54.