We attempted to investigate the effects of GE on scopolamine‐induced amnesia in rats using water maze test. Wistar rats were randomly allocated into 4 groups. Each group received 100, 500, or 1,000 mg/kg of the GE or cellulose daily for two week. After one week, scopolamine (0.5 mg/kg, i.p.) was administered 30 min daily before water maze test. The latency to find the platform was obtained in acquisition trial and working memory task and total time spent in the previous target quadrant was analyzed in probe trial. The control group administered cellulose for 1 week and scopolamine 30 min before water maze test showed significant increases in latency time in both acquisition trial and working memory task and time spent in the previous target quadrant in probe trial. The GE group treated with GE 500 mg/kg for 1 week and scopolamine 30 min before water maze test demonstrated significantly less latency time in acquisition trial compared to the control group. No significant differences were found in latency time in working memory task and total time spent in the previous target quadrant in probe trial. Our results suggest that GE may have ameliorating effects on the scopolamine induced amnesia in rats. Further studies need to be pursued to investigate long‐term effects of GE.
To investigate the effects of lecithin extracted from Japanese anchovy on blood passage and serum lipid profile were assessed in vivo. Sprague Dawley strain rats were divided into five groups of ten rats each; normal control, negative control and three dosages of lecithin treated groups (80, 200 and 500 mg/kg). Serum total cholesterol, triglyceride, LDL‐cholesterol, atherogenic index (AI) and cardiac risk factor (CRF) contents were significantly reduced in the lecithin treated groups compared to the negative control group (P<0.05). The level of serum serotonin in the lecithin treated groups was significantly reduced compared to the negative control group (P<0.05). The platelet aggregation was inhibited in lecithin treated groups. There was no significant difference compared to the negative control group. Blood passage time of the lecithin treated group showed a tendency to decrease compared to the negative control group, which was studied with micro channel array flow analyzer (MC‐FAN). Also, in the histopathological assay of aorta wall lumen, the cholesterol aggregation level in the lecithin treated groups was reduced compared to the negative control group. All these results suggest that Japanese anchovy‐extracted lecithin might have anti‐atherogenic effect via lipid profile improvement.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.