Spin-dependent conductance across a manganate-barrier-manganate junction has recently been demonstrated. The junction is a La 0.67 Sr 0.33 MnO 3 -SrTiO 3 -La 0.67 Sr 0.33 MnO 3 trilayer device supporting current-perpendicular transport. Large magnetoresistance of up to a factor of five change was observed in these junctions at 4.2K in a relatively low field of the order of 100 Oe. Temperature and bias dependent studies revealed a complex junction interface structure whose materials physics has yet to be understood.