Spontaneous rupture of hepatocellular carcinoma (HCC) is a potentially lethal complication. Despite various treatment modalities with curative intent, there are scant data on ruptured cases achieving complete pathological response (pCR), with only a handful of case reports. We report a case of a Chinese male patient with large advanced HCC (aHCC) first detected with rupture in an emergency setting, developing a pCR after multidisciplinary onco-surgical approach.
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