The synthesis of two series of five
kaempfer-3-ols was described.
The first set all have a C-3 hydroxyl group and the
second has a carboxymethoxy ether at the C-3 position.
Both series have variable substitution at the C-4′
position (i.e., OH, Cl, F, H, OMe). Both kaempferols and carboxymethoxy
ethers were evaluated for their ability to inhibit ribosomal s6 kinase
(RSK) activity and cancer cell proliferation.
The development and application of the asymmetric synthesis of oligosaccharides from achiral starting materials is reviewed. This de novo asymmetric approach centers around the use of asymmetric catalysis for the...
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