Bronchiolitis obliterans syndrome (BOS) is the most common form of lung chronic graft-versus-host disease (cGVHD) after allogeneic hematopoietic cell transplantation, often presenting as severe airflow obstruction. Prior studies have shown associations between quantitative CT (qCT) air trapping (AT) and airway morphometry (AM) measurements and FEV1 impairment. We developed qCT methods to measure voxel-level changes in the magnitude and direction of lung deformation from inspiration to expiration (I/E). We hypothesized that lung deformation would better capture the extent of pulmonary impairment in BOS as compared to classic AT or AM indices.
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