Sonodynamic
therapy (SDT) can be described as ultrasonic
(US) catalysis.
Adequate charge separation is considered as effective means to promote
reactive oxygen species (ROS). Here, hollow CoP@N–carbon@PEG
(CPCs@PEG) nanospheres (∼60 nm) are prepared as sonosensitizers,
showing greater ROS generation than pure CoP@PEG under US irradiation.
Both 1O2 and ·O2
– are activation species that are determined by O2 and
electrons. The great SDT performance of CPCs@PEG is ascribed to the
heterostructure which promotes the separation and transfer for US-generated
electrons and holes. In addition, holes can be further captured by
endogenous glucose that is in favor of electron aggregation and ROS
generation. Moreover, the consumption of glucose would decrease intracellular
ATP for starvation therapy. Given the higher oxidation ability of
Co3+, CPCs@PEG nanospheres possess catalase (CAT) activity
to convert H2O2 into O2 for assisting
ROS generation. Moreover, they also can oxidize glutathione (GSH)
as a mimic GSH oxidase to break intratumor redox balance, facilitating
oxidative stress. More importantly, the nanocomposites reveal good
degradation ability dominated by the oxidation from insoluble phosphide
into soluble phosphate, accelerating elimination via urine and feces
within 14 days. CPCs@PEG nanospheres integrate the above effects not
only to reveal great tumor inhibition ability but also to excite immune
activation for anticancer.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.