SUMMARY BackgroundThe impact of constipation on quality of life (QoL) may vary in different cultural or national settings.

SUMMARY BackgroundWhile numerous studies report prevalence of constipation, use of laxatives is poorly understood.

Co-administration of PR oral naloxone and PR oral oxycodone is associated with a significant improvement in bowel function compared with PR oral oxycodone alone, with no reduction in the analgesic efficacy of oxycodone.

Treatment of chronic constipation with SPS improves bowel function, symptoms, and QoL and is well tolerated. The dose can be adjusted individually while maintaining benefit.