Atypical desmosomes are found between cells at the bottom of the lacunae in Darier’s disease. The spacing between the intermediate dense lines may be irregularly reduced, and the extracellular material can exhibit an uneven moth-eaten aspect; the intercellular contact layer is missing, but tonofibrils are connected to the attachment plaques. These desmosomes are interpreted as malformations. Desmosomes with a dilated intercellular gap are expected to split in two halves.

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