Background: Guillain Barre syndrome (GBS) is a progressive symmetric muscular weakness with absent or depressed deep tendon reflexes. Wide spectrum of disease severity can be seen ranging from a mild disease to quadriparesis, cranial nerve involvement and autonomic instability. Methods: Hospital based observational study is planned for GBS patients admitted to Cheluvamba hospital, a tertiary care hospital in South India, for a period of 2.5 years from Jan 2020 to August 2022.Results: 30 patients (12 males; 18 females; mean age of 7.7 years) were enrolled in this study. Among which 11 were in age group of 0-5 (36%), 10 were in the age group of 6-10 (33%), 7 were in age group of 10-15 (23%), 2 were in age group 16 and above (6.6%). Type of paralysis was paraparesis in 14 (46%) children quadriparesis in 15 (50%) children and one child had no limb involvement. In associated dysfunctions, autonomic dysfunction was seen in 1 (4.5%), bulbar palsy in 3 (13.6%). One child presented with features of Miller Fischer variant of GBS which are ophthalmoplegia and ataxia. Among 30 children 22 were recovered and discharged, 3 children died, and 5 children left against medical advice.Conclusions: The clinical characteristics, subtype of GBS, and outcome vary according to geographic area. This study is directed to find the clinical pattern and outcome of the same in tertiary care hospital in south India.
Background: Exclusive breastfeeding is an essential part of early infant feeding. Promotion of EBF is the most effective way to reduce the infant mortality rate. This study was carried out to identify factors affecting EBF among mothers attending Narayana medical college hospital Nellore. Aim and objectives of the study was to know the incidence of lactation failure and to evaluate the factors responsible for lactation failure.Methods: Hospital-based cross-sectional study conducted from July 2018 to September 2018 involving a total of 100 mothers with the help of a proforma containing predesigned questionnaire. Demographic data of mother, obstetric details, mode of delivery, birth weight, details of antenatal advice about breastfeeding and practices, pre-lacteal feeds, current feeding practice, problems encountered during breastfeeding, anatomical problems were noted. The data collected were tabulated and statistically analyzed.Results: At the end of the study, among 100 mothers, 24 mothers are reported to have lactation failure and feeding babies with formula feeds. Among the variables taken into consideration pre-lacteal feeds, problems encountered during breastfeeding, breast diseases showed a statistically significant association with lactation failure. Mean weight gain in breastfeeding mothers and mothers with lactation failure is 11.3 kgs and 10.04 kgs respectively. Mean hemoglobin in breastfeeding mothers and mothers with lactation failure is 10.43 g/dl and 9.91 g/dl respectively.Conclusions: The results provide information about the relation between breastfeeding failure and its association with factors that contribute to it.
Severe Childhood Autosomal Recessive Muscular Dystrophy (SCARMD) is a variant of sarcoglycanopathy resulting from mutation in the sarcoglycan genes. SCARMD is a rare form of muscular dystrophy characterised by severe DMD like phenotype occurring at early ages and affecting boys as well as girls. Here we are reporting a case of 7year old female child born to 3rd degree consanguineous parents presented with proximal muscle weakness beginning in both lower limbs since4 years of age. On thorough clinical examination and laboratory evaluation child turned out to be SCARMD. Hence this case report emphasizes that suspicion of SCARMD has to be made when female children presented with features of DMD, and genetic counselling and prenatal diagnosis should be done to reduce the burden of the disease in the community.
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