The molecular origin behind the concentration-dependent intrinsic blue fluorescence of human serum albumin (HSA) is not known yet. This unusual blue fluorescence is believed to be a characteristic feature of amyloid-like fibrils of protein/peptide and originates due to the delocalization of peptide bond electrons through the extended hydrogen bond networks of cross-β-sheet structure. Herein, by combining the results of spectroscopy, size exclusion chromatography, native gel electrophoresis, and confocal microscopy, we have shown that the intrinsic blue fluorescence of HSA exclusively originates from oligomeric interfaces devoid of any amyloid-like fibrillar structure. Our study suggests that this low energy fluorescence band is not due to any particular residue/sequence, but rather it is a common feature of self-assembled peptide bonds. The present findings of intrinsic blue fluorescence from oligomeric interfaces pave the way for future applications of this unique visual phenomenon for early stage detection of various protein aggregation related human diseases.

The use of metal-free diacetylene based polymers to resolve environmental problems is an emerging field of research interest. In this study, two dipeptide functionalized diacetylene based compounds were synthesized. Compound 1 self-assembles to form organogels under certain conditions. Exposure of UV light irradiation on organogel results in the formation of one-dimensional polydiacetylene based conjugated nanoporous covalent organic polymer (PDA-COP 1) nanostructures that demonstrate significant recyclable photocatalytic dye degradation and substantial CO 2 capture ability. Under visible light irradiation, 92% methyl orange degradation is achieved in the presence of PDA-COP 1 after 120 min without the support of any sacrificial reagents or precious metal cocatalysts. Remarkably, surface area is tuned from 0.001 m 2 g −1 (compound 1) to 260.484 m 2 g −1 for the lightinduced developed nanoporous covalent organic polymer (PDA-COP 1). In addition, CO 2 uptake by PDA-COP 1 is increased by 2.45 times more than the CO 2 uptake by the respective monomeric compound 1.

Porous covalent organic polymers were prepared from self-assembled fibers using a topochemical polymerization reaction and their four times higher CO2 sorption behaviour is demonstrated.

Self‐assembled structure and functions of peptides could be achieved by the design and synthesis of hybrid peptides. Here, we report structural and morphological studies of designed hybrid tripeptides Boc‐Gpn‐Aib‐Xaa‐OMe (where Xaa=Leu(L) for 1 and Phe(F) for 2), which show different conformations both in solid and solution states. The conformational modulations are achieved by the design and synthesis of reported peptides 1 and 2 by suitable choice of conventional and non‐conventional amino acid building blocks and slight change in side‐chain of third amino acids of tripeptides. The conformational modulations exhibited by peptides 1 and 2 are well probed and confirmed using Single crystal XRD, FT‐IR, CD and 2D NMR studies. The morphological studies of peptides 1 and 2 show different self‐assembled morphological preferences in THF – water (1:1) under similar experimental conditions.