Quantification of cardiac deformation and strain with 3D ultrasound takes considerable research efforts. Nevertheless, a widespread use of these techniques in clinical practice is still held back due to the lack of a solid verification process to quantify and compare performance. In this context, the use of fully synthetic sequences has become an established tool for initial in silico evaluation. Nevertheless, the realism of existing simulation techniques is still too limited to represent reliable benchmarking data. Moreover, the fact that different centers typically make use of in-house developed simulation pipelines makes a fair comparison difficult. In this context, this paper introduces a novel pipeline for the generation of synthetic 3D cardiac ultrasound image sequences. State-of-the art solutions in the fields of electromechanical modeling and ultrasound simulation are combined within an original framework that exploits a real ultrasound recording to learn and simulate realistic speckle textures. The simulated images show typical artifacts that make motion tracking in ultrasound challenging. The ground-truth displacement field is available voxelwise and is fully controlled by the electromechanical model. By progressively modifying mechanical and ultrasound parameters, the sensitivity of 3D strain algorithms to pathology and image properties can be evaluated. The proposed pipeline is used to generate an initial library of 8 sequences including healthy and pathological cases, which is made freely accessible to the research community via our project web-page.

Rule‐based methods are often used for assigning fiber orientation to cardiac anatomical models. However, existing methods have been developed using data mostly from the left ventricle. As a consequence, fiber information obtained from rule‐based methods often does not match histological data in other areas of the heart such as the right ventricle, having a negative impact in cardiac simulations beyond the left ventricle. In this work, we present a rule‐based method where fiber orientation is separately modeled in each ventricle following observations from histology. This allows to create detailed fiber orientation in specific regions such as the endocardium of the right ventricle, the interventricular septum, and the outflow tracts. We also carried out electrophysiological simulations involving these structures and with different fiber configurations. In particular, we built a modeling pipeline for creating patient‐specific volumetric meshes of biventricular geometries, including the outflow tracts, and subsequently simulate the electrical wavefront propagation in outflow tract ventricular arrhythmias with different origins for the ectopic focus. The resulting simulations with the proposed rule‐based method showed a very good agreement with clinical parameters such as the 10 ms isochrone ratio in a cohort of nine patients suffering from this type of arrhythmia. The developed modeling pipeline confirms its potential for an in silico identification of the site of origin in outflow tract ventricular arrhythmias before clinical intervention.

This is an encouraging first step towards a noninvasive preoperative prediction of the response to different pacing conditions to assist clinicians for CRT patient selection and therapy planning.

The forecast of tropical cyclone trajectories is crucial for the protection of people and property. Although forecast dynamical models can provide high-precision short-term forecasts, they are computationally demanding, and current statistical forecasting models have much room for improvement given that the database of past hurricanes is constantly growing. Machine learning methods, that can capture non-linearities and complex relations, have only been scarcely tested for this application. We propose a neural network model fusing past trajectory data and reanalysis atmospheric images (wind and pressure 3D fields). We use a moving frame of reference that follows the storm center for the 24h tracking forecast. The network is trained to estimate the longitude and latitude displacement of tropical cyclones and depressions from a large database from both hemispheres (more than 3000 storms since 1979, sampled at a 6 hour frequency). The advantage of the fused network is demonstrated and a comparison with current forecast models shows that deep learning methods could provide a valuable and complementary prediction. Moreover, our method can give a forecast for a new storm in a few seconds, which is an important asset for real-time forecasts compared to traditional forecasts.

Abstract-Goal: Non-invasive cardiac electrophysiology (EP) model personalisation has raised interest for instance in the scope of predicting EP cardiac resynchronization therapy (CRT) response. However, the restricted clinical applicability of current methods is due in particular to the limitation to simple situations and the important computational cost. Methods: We propose in this manuscript an approach to tackle these two issues. First, we analyse more complex propagation patterns (multiple onsets and scar tissue) using relevance vector regression and shape dimensionality reduction on a large simulated database. Second, this learning is performed offline on a reference anatomy and transferred onto patient-specific anatomies in order to achieve fast personalised predictions online. Results: We evaluated our method on a dataset composed of 20 dyssynchrony patients with a total of 120 different cardiac cycles. The comparison with a commercially available electrocardiographic imaging (ECGI) method shows a good identification of the cardiac activation pattern. From the cardiac parameters estimated in sinus rhythm, we predicted 5 different paced patterns for each patient. The comparison with the body surface potential mappings (BSPM) measured during pacing and the ECGI method indicates a good predictive power. Conclusion: We showed that learning offline from a large simulated database on a reference anatomy was able to capture the main cardiac EP characteristics from non-invasive measurements for fast patient-specific predictions. Significance: The fast CRT pacing predictions are a step forward to a noninvasive CRT patient selection and therapy optimisation, to help clinicians in these difficult tasks.