Prostate cancer is one of the most common cancers among workers of various industries that depend on nickel extensively, through different mechanisms. Our present study is designed to estimate nickel concentrations in serum samples from patients with prostate cancer compared to the control group of healthy subjects. The study was carried out on 43 patients with prostate cancer at Al-Biruni University Hospital for Cancerous Diseases in Syria compared with 35 healthy controls. All measurements of serum were done with a graphite atomic absorption spectrophotometer equipped with a deuterium lamp. Our results showed that patients with prostate cancer had significantly higher serum levels of Ni than healthy controls (p < 0.0001). These findings suggest that increased nickel serum levels are associated with an increased risk of prostate cancer in industrial workers through one of the carcinogenic mechanisms.
Benzo[a]pyrene (B[a]P) is a major polycyclic aromatic hydrocarbon (PAH), it can bind the DNA to produce DNA-adducts, which has major carcinogenic potential. Enzyme-linked immunosorbet assay (ELISA) is the method used to detect these DNA adducts of B[a] P diolepoxide (BPDE) within the living cells.The aim of this study is to evaluate exposure to bitumen fumes, and to B[a]P in asphalt plant workers by measuring the BPDE-DNA adducts in their peripheral white blood cells (WBC), which are considered biological markers for exposure risk assessment. In this study, Hemostatic blood (CBC, AST) were measured, and the levels of BPDE-DNA adducts were measured in DNA samples of WBC obtained from asphalt plant workers in Syria and compared to those measured from a control group. The measurement was performed using BPDE-DNA Adducts ELISA.kit. The sample size was determined to be 50 with 25 asphalt plant workers and 25 healthy volunteers with no occupational exposure to PAHs.The results showed some diseases associated with exposure to asphalt fumes among the workers in the study group and a statistically significant difference in the values of (CBC; WBC, leukocytes, HCT, MCHC and AST) between the study group and the control group. BPDE-DNA adducts were detected in WBC of 11 asphalt plant workers with concentrations ranging between 0 and 2.75 ng/ml and only one individual in the control group with concentration of 0.75 ng/ml. These results indicate significant positive relationship between exposure to the bitumen fumes and formation of BPDE-DNA adducts.BPDE-DNA adducts is potential biomarker for PAHs exposure and likely helpful indicator of PAH-induced DNA damage and possibly carcinogenesis.
On a daily basis, individuals are exposed to potential poisoning by different sources such as medicines, food, alcohol, pesticides, and chemical cleaning materials. In these circumstances, individuals often need to undergo medical emergency interventions to manage the serious consequences that can appear simultaneously with the poisoning or in the long term. Indeed, the nature and circumstances of daily poisoning cases vary among sociodemographic backgrounds. This fact requires the development of a medical emergency system that integrates emergency toxicity treatments. This perspective further suggests the development of appropriate prevention and treatment programs according to the geographical distribution of the recorded daily poisoning incidences. A database was built in regards to the many acute poisoning cases recorded in a number of emergency facilities based on four geographical zones in Syria. The data included the source of the poisoning and the individual's identity demographics, like age, gender, profession, the area of residence, and employment. The statistical analysis proved that there is an evident relationship between the types of
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