Self-assembling
peptides and oligonucleotides have given rise to
synthetic materials with several applications in nanotechnology. Aggregation
of synthetic oligosaccharides into well-defined architectures has
not been reported even though natural polysaccharides, such as cellulose
and chitin, are key structural components of biomaterials. Here, we
report that six synthetic oligosaccharides, ranging from dimers to
hexamers, self-assemble into nanostructures of varying morphologies
and emit within the visible spectrum in an excitation-dependent manner.
Well-defined differences in chain length, monomer modification, and
aggregation methods yield glycomaterials with distinct shapes and
properties. The excitation-dependent fluorescence in a broad range
within the visible spectrum illustrates their potential for use in
optical devices and imaging applications. We anticipate that our systematic
approach of studying well-defined synthetic oligosaccharides will
form the foundation of our understanding of carbohydrate interactions
in nature.
Carbohydrates are abundant biomolecules, with a strong tendency to form supramolecular networks. A host of carbohydrate-based nanomaterials have been exploited for biomedical applications. These structures are based on simple monoor disaccharides, as well as on complex, polymeric systems. Chemical modifications serve to tune the shapes and properties of these materials. In particular, carbohydrate-based nanoparticles and nanogels were used for drug delivery, imaging, and tissue engineering applications. Due to the reversible nature of the assembly, often based on a combination of hydrogen bonding and hydrophobic interactions, carbohydrate-based materials are valuable substrates for the creations of responsive systems. Herein, we review the current research on carbohydratebased nanomaterials, with a particular focus on carbohydrate assembly. We will discuss how these systems are formed and how their properties are tuned. Particular emphasis will be placed on the use of carbohydrates for biomedical applications.
Hierarchical carbohydrate architectures serve multiple roles in nature. Hardly any correlations between the carbohydrate chemical structures and the material properties are available due to the lack of standards and suitable analytic techniques. Therefore, designer carbohydrate materials remain highly unexplored, as compared to peptides and nucleic acids. A synthetic d-glucose disaccharide, DD, was chosen as a model to explore carbohydrate materials. Microcrystal electron diffraction (MicroED), optimized for oligosaccharides, revealed that DD assembled into highly crystalline left-handed helical fibers. The supramolecular architecture was correlated to the local crystal organization, allowing for the design of the enantiomeric right-handed fibers, based on the l-glucose disaccharide, LL, or flat lamellae, based on the racemic mixture. Tunable morphologies and mechanical properties suggest the potential of carbohydrate materials for nanotechnology applications.
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