OBJECTIVE: To determine the relationship between two common apoA-IV variants (Thr 347 ?Ser; Gln 360 ?His), and body mass index (BMI) and percentage body fat. DESIGN: Cross-sectional study. SUBJECTS: Eight-hundred and forty-eight subjects screened for participation in ongoing clinical studies. MEASUREMENTS: ApoA-IV genotype, body mass index, waist-to-hip ratio and percentage body fat by bioelectric impedance. RESULTS: Participants had an average age of 41 AE 12 y and an average BMI of 28.2 AE 5.5 kgam 2 . Individuals homozygous for the Ser 347 allele had higher BMI (32.3 AE 6.6 vs 28.6 AE 5.3 kgam 2 ; P`0.01) and percentage body fat (36.9 AE 7.8 vs 31.0 AE 9.6%; P`0.05) compared with individuals homozygous for Thr 347 . In contrast, the presence of at least one copy of the His 360 allele was associated with lower BMI (27.2 AE 5.0 vs 28.4 AE 5.6 kgam 2 ; P`0.05) and percentage body fat (28.6 AE 8.2 vs 30.7 AE 9.1%; P`0.05). The genotype effects persisted after normalization of the data for the potential confounding effects of gender, age and race. When grouped by BMI percentile, the frequency of the Ser 347 aSer 347 genotype increased while the frequency of the His 360 allele decreased with increasing BMI. CONCLUSIONS: These data suggest a role for apoA-IV in fat storage or mobilization and that genetic variations in the apoA-IV gene may play a role in the development of obesity.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.