Guided tissue regeneration (GTR) is a promising treatment for periodontal tissue defects, which generally uses a membrane to build a mechanical barrier from the gingival epithelium and hold space for the periodontal regeneration especially the tooth-supporting bone. However, existing membranes possess insufficient mechanical properties and limited bioactivity for periodontal bone regenerate. Herein, fish collagen and polyvinyl alcohol (Col/PVA) dual-layer membrane were developed via a combined freezing/thawing and layer coating method. This dual-layer membrane had a clear but contact boundary line between collagen and PVA layers, which were both hydrophilic. The dual membrane had an elongation at break of 193 ± 27% and would undergo an in vitro degradation duration of more than 17 days. Further cell experiments showed that compared with the PVA layer, the collagen layer not only presented good cytocompatibility with rat bone marrow-derived mesenchymal stem cells (BMSCs), but also promoted the osteogenic genes (RUNX2, ALP, OCN, and COL1) and protein (ALP) expression of BMSCs. Hence, the currently developed dual-layer membranes could be used as a stable barrier with a stable degradation rate and selectively favor the bone tissue to repopulate the periodontal defect. The membranes could meet the challenges encountered by GTR for superior defect repair, demonstrating great potential in clinical applications.
In
this study, a fully biobased benzoxazine monomer (E-s) was combined
with SiO2 nanoparticles to construct superhydrophobic/superoleophilic
coatings on polyethylene terephthalate fabrics by spray coating and
thermal curing. The resulting PE-s/SiO20.2 fabric possessed
special wettability with a water contact angle of 156.2 ± 1.5°
and a sliding angle of 5.2 ± 1.0°, and it exhibited great
adhesion strength under ultrasonication. Furthermore, PE-s/SiO20.2 fabrics achieved ultrafast and efficient separation with
average oil fluxes of around 45,000 L/m2 h and separation
efficiencies over 93% for several oil/water mixtures. In addition,
PE-s/SiO20.2 fabrics showed strong durability under several
types of harsh treatment. Both their superwettability and separation
performance were steadily preserved after immersion in acidic/alkaline
solutions with pH values of 1–11 for 1 h, solvent immersion
for 100 h, and 44 cycles of abrasion. Finally, a simple rinsing operation
was explored to clean polluted PE-s/SiO20.2 fabrics.
Two-way coupling between pH-responsive phase separation of enzyme-polymer mixtures and reaction-induced pH changes creates negative feedback in these active coacervates.
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